Kallikrein 10 (KLK10)
[Edit]NES1; PRSSL1; Kallikrein-Related Peptidase 10; Normal epithelial cell-specific 1; Protease serine-like 1
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KLK10 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
The deduced 276-amino acid protein contains a putative signal peptide, followed by a short activating peptide and the protease domain, which includes the catalytic triad of his86, asp137, and ser229. KLK10 also contains 12 conserved cysteines in its protease domain that are expected to form 6 disulfide bonds, as in other serine proteases. RT-PCR detected variable levels of KLK10 expression in nearly all of the 35 adult and fetal tissues examined.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA697Hu01 | Recombinant Kallikrein 10 (KLK10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA697Hu01 | Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. |
| MAA697Hu22 | Monoclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. | |
| LAA697Hu71 | Biotin-Linked Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC. | |
| Assay Kits | CEA697Hu | ELISA Kit for Kallikrein 10 (KLK10) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CCA697Hu | CLIA Kit for Kallikrein 10 (KLK10) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | CPA697Mu21 | OVA Conjugated Kallikrein 10 (KLK10) | Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA697Mu01 | Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. |
| PAA697Mu08 | Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Kallikrein 10 (KLK10) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kallikrein 10 (KLK10) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | CPA697Ra21 | OVA Conjugated Kallikrein 10 (KLK10) | Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA697Ra01 | Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. |
| PAA697Ra08 | Polyclonal Antibody to Kallikrein 10 (KLK10) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Kallikrein 10 (KLK10) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Kallikrein 10 (KLK10) | ELISA Kit Customized Service Offer |
- "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression."Cancer Res. 56:3371-3379(1996) [PubMed] [Europe PMC] [Abstract]
- "Structural characterization and mapping of the normal epithelial cell-specific 1 gene."Biochem. Biophys. Res. Commun. 247:580-586(1998) [PubMed] [Europe PMC] [Abstract]
- "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker."Tumor Biol. 26:227-235(2005) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The role for NES1 serine protease as a novel tumor suppressor."Cancer Res. 58:4782-4786(1998) [PubMed] [Europe PMC] [Abstract]