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Kallikrein 6 (KLK6)

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ZYME; Bssp; Klk7; Neurosin,Zyme; PRSS18; PRSS9; SP59; HK6; Protease M; Serine protease 18

Kallikrein 6 (KLK6)
CCC A691
HGNC 6367
MGI 1343166
PubMed 20836755
RGD 3419
UniProt Q92876
Wiki KLK6

Kallikrein 6, also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikrein 6 was originally described from the brain as an enzyme involved in degradation of amyloid plaque protein (APP) and hK6 was thought to be a beta secretase.

Kallikrein 6 was shown to be elevated in the sera patients with Alzheimer’s disease and Parkinson’s disease and in animal models of multiple sclerosis. The neuronal protein alpha-synuclein was shown to be cleaved by hK6, as has APP and hK6 has been implicated in vascular morphogenesis and angiogenesis. MSP has also been shown to rapidly degrade myelin-specific protein, laminin and fibronectin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA691Hu01 Recombinant Kallikrein 6 (KLK6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA691Hu01 Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
MAA691Hu22 Monoclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
LAA691Hu81 FITC-Linked Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IF.
LAA691Hu71 Biotin-Linked Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC.
Assay Kits CEA691Hu ELISA Kit for Kallikrein 6 (KLK6) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA691Hu ELISA Kit for Kallikrein 6 (KLK6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA691Mu01 Recombinant Kallikrein 6 (KLK6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA691Mu02 Recombinant Kallikrein 6 (KLK6) Positive Control; Immunogen; SDS-PAGE; WB.
EPA691Mu61 Eukaryotic Kallikrein 6 (KLK6) Positive Control; Immunogen; SDS-PAGE; WB.
APA691Mu61 Active Kallikrein 6 (KLK6) Cell culture; Activity Assays.
Antibodies PAA691Mu01 Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
LAA691Mu81 FITC-Linked Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IF.
LAA691Mu71 Biotin-Linked Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC.
PAA691Mu02 Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
Assay Kits SEA691Mu ELISA Kit for Kallikrein 6 (KLK6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA691Ra01 Recombinant Kallikrein 6 (KLK6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA691Ra01 Polyclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
MAA691Ra21 Monoclonal Antibody to Kallikrein 6 (KLK6) WB; IHC; ICC; IP.
Assay Kits SEA691Ra ELISA Kit for Kallikrein 6 (KLK6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel protease homolog differentially expressed in breast and ovarian cancer."Mol. Med. 2:624-636(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain."Biochim. Biophys. Acta 1350:11-14(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain."J. Biol. Chem. 272:25135-25142(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease."Genomics 62:251-259(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and characterization of novel isoforms of the human kallikrein 6 gene."Biochem. Biophys. Res. Commun. 320:54-61(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer."Biol. Chem. 387:773-782(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications."Clin. Biochem. 33:369-375(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease."Psychiatry Clin. Neurosci. 54:419-426(2000) [PubMed] [Europe PMC] [Abstract]
  13. "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry."J. Histochem. Cytochem. 49:1431-1441(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors."Biochem. Biophys. Res. Commun. 307:948-955(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies."Hum. Mol. Genet. 12:2625-2635(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells."Tumor Biol. 25:193-199(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Dynamic role of kallikrein 6 in traumatic spinal cord injury."Eur. J. Neurosci. 24:1457-1469(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects."J. Biol. Chem. 281:3116-3126(2006) [PubMed] [Europe PMC] [Abstract]
  19. "The autolytic regulation of human kallikrein-related peptidase 6."Biochemistry 46:5209-5217(2007) [PubMed] [Europe PMC] [Abstract]
  20. "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family."J. Biol. Chem. 277:27273-27281(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system."J. Biol. Chem. 277:24562-24570(2002) [PubMed] [Europe PMC] [Abstract]