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Kallikrein 8 (KLK8)

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NP; HNP; NRPN; PRSS19; TADG14; BSP1; Neuropsin; Ovasin; Brain Serine Protease 1; Tumor Associated Differentially Expressed Gene 14; Serine protease 19

Kallikrein 8 (KLK8)
CCC A690
HGNC 6369
MGI 1343327
PubMed 17178872
RGD 1305998
UniProt O60259
Wiki Kallikrein_8

Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients.

Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates.Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA690Hu01 Recombinant Kallikrein 8 (KLK8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA690Hu01 Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IP.
MAA690Hu22 Monoclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IP.
Assay Kits CEA690Hu ELISA Kit for Kallikrein 8 (KLK8) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA690Hu ELISA Kit for Kallikrein 8 (KLK8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA690Mu01 Recombinant Kallikrein 8 (KLK8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA690Mu01 Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IP.
LAA690Mu81 FITC-Linked Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IF.
LAA690Mu71 Biotin-Linked Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC.
Assay Kits SEA690Mu ELISA Kit for Kallikrein 8 (KLK8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA690Ra01 Recombinant Kallikrein 8 (KLK8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA690Ra01 Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IP.
LAA690Ra81 FITC-Linked Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC; IF.
LAA690Ra71 Biotin-Linked Polyclonal Antibody to Kallikrein 8 (KLK8) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Kallikrein 8 (KLK8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kallikrein 8 (KLK8) ELISA Kit Customized Service Offer
  1. "Sequence analysis and expression of human neuropsin cDNA and gene."Gene 213:9-16(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma."Cancer Res. 59:4435-4439(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain."Eur. J. Biochem. 260:627-634(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer."Clin. Cancer Res. 7:806-811(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory."Mol. Biol. Evol. 21:2111-2115(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of the kallikrein gene family in normal and Alzheimer's disease brain."NeuroReport 12:2747-2751(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples."Mol. Pathol. 55:235-241(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Human kallikrein 8, a novel biomarker for ovarian carcinoma."Cancer Res. 63:2771-2774(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins."FEBS Lett. 579:6879-6884(2005) [PubMed] [Europe PMC] [Abstract]
  14. "A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory."Hum. Mutat. 28:978-984(2007) [PubMed] [Europe PMC] [Abstract]
  15. "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
  16. "SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]