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Dopamine Receptor D2 (DRD2)

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DR-D2; D2DR; D2R

Dopamine Receptor D2 (DRD2)
CCC A673
HGNC 3023
MGI 94924
PubMed 12554675
RGD 2520
UniProt P14416
Wiki DRD2

D2 (DRD2). There is a short version of D2 (D2Sh) and a long version of D2 (D2Lh): The D2Sh are pre-synaptic situated, having modulatory functions (called autoreceptor, they regulate the neurotransmission by feed-back mechanisms, i.e., synthesis, storage and release of dopamine into the synaptic cleft).

The D2Lh may have the classic function of a post-synaptic receptor, i.e., keep going on the neurotransmission (excitatory or inhibitory) once blocked by a receptor antagonist or stimulated by the endogenous neurotransmitter itself or a synthetic full or partial agonist.D2-like activation is coupled to the G protein Gαi, which subsequently increases phosphodiesterase activity. Phosphodiesterases break down cAMP, producing an inhibitory effect in neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Hu01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Hu02 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Hu01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
MAA673Hu22 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Hu ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Mu01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Mu02 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Mu01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) Testing in progress
Assay Kits SEA673Mu ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ra01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra02 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra03 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra04 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra05 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ra01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB
MAA673Ra21 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB
MAA673Ra22 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB
Assay Kits SEA673Ra ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ca01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ca01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB
Assay Kits n/a CLIA Kit for Dopamine Receptor D2 (DRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D2 (DRD2) ELISA Kit Customized Service Offer
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  9. "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2."Neuropsychopharmacology 8:137-142(1993) [PubMed] [Europe PMC] [Abstract]
  10. "New dopamine receptor, D2(Longer), with unique TG splice site, in human brain."Brain Res. Mol. Brain Res. 76:132-141(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool."J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions."Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity."Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract]
  17. ErratumProc. Natl. Acad. Sci. U.S.A. 109:1808-1808(2012) [PubMed] [Europe PMC] [Abstract]
  18. "A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)."Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Association of a missense change in the D2 dopamine receptor with myoclonus dystonia."Proc. Natl. Acad. Sci. U.S.A. 96:5173-5176(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics."Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia." Ann. Neurol. 47:369-373(2000) [PubMed] [Europe PMC] [Abstract]
  22. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]