Amiloride Binding Protein 1 (ABP1)

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AOC1; DAO; KAO; Histaminase; Kidney amine oxidase; Diamine Oxidase; Amiloride-sensitive amine oxidase; Amine oxidase copper domain-containing protein 1

Amiloride Binding Protein 1 (ABP1)

On the basis of its primary structure, the amiloride-binding protein (EC 1.4.3.6) is 713 amino acids long, with a 19-amino acid signal peptide. Expressed in cultured cells, the mRNA yields a glycoprotein that binds amiloride and amiloride analogs with affinities similar to the amiloride receptor associated with the apical Na+ channel in pig kidney membranes and is immunoprecipitated with monoclonal antibodies raised against pig kidney amiloride-binding protein. Barbry et al. (1990) pointed out that amiloride-sensitive Na+ channels are also present in airway epithelia, where they play an important role in fluid secretion. Amiloride inhibits the excessive absorption of Na+ and liquid that takes place in airway epithelia of patients with cystic fibrosis, and amiloride aerosol therapy has been tried for the treatment of lung disease in CF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA656Hu01 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA656Hu61 Active Amiloride Binding Protein 1 (ABP1) Cell culture; Activity Assays.
EPA656Hu61 Eukaryotic Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA656Hu02 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA656Hu01 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP; FCM
MAA656Hu22 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB,IHC
LAA656Hu71 Biotin-Linked Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC.
PAA656Hu02 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu21 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu23 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu24 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu25 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu27 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Hu29 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
Assay Kits SEA656Hu ELISA Kit for Amiloride Binding Protein 1 (ABP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA656Mu01 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA656Mu02 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA656Mu01 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
LAA656Mu71 Biotin-Linked Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC.
PAA656Mu02 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
Assay Kits SEA656Mu ELISA Kit for Amiloride Binding Protein 1 (ABP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA656Ra01 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA656Ra02 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA656Ra01 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
PAA656Ra02 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
LAA656Ra71 Biotin-Linked Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC.
MAA656Ra21 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
MAA656Ra22 Monoclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
Assay Kits SEA656Ra ELISA Kit for Amiloride Binding Protein 1 (ABP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA656Po01 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA656Po02 Recombinant Amiloride Binding Protein 1 (ABP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA656Po01 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
PAA656Po02 Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC; IP.
LAA656Po71 Biotin-Linked Polyclonal Antibody to Amiloride Binding Protein 1 (ABP1) WB; IHC; ICC.
Assay Kits SEA656Po ELISA Kit for Amiloride Binding Protein 1 (ABP1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human kidney amiloride-binding protein: cDNA structure and functional expression."Proc. Natl. Acad. Sci. U.S.A. 87:7347-7351(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter."J. Biol. Chem. 269:14484-14489(1994) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequences of variant forms of human placenta diamine oxidase."Biochem. Genet. 33:261-268(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues."J. Biol. Chem. 269:9921-9925(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and inhibition of human diamine oxidase."Biochemistry 48:9810-9822(2009) [PubMed] [Europe PMC] [Abstract]