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Myeloperoxidase (MPO)

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Myeloperoxidase (MPO)
CCC A601
HGNC 7218
MGI 97137
PubMed 10519157
RGD 1592081
UniProt P05164
Wiki Myeloperoxidase

Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in polymorphonuclear leukocytes (neutrophils) and secreted during their activation. The presence of a peroxidase in the cytoplasmic granules of leukocytes was suggested at the beginning of 20th century but it was the early 1940s that it was purified for the first time.

Native MPO is a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 – 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW about 150 kDa and theoretical pI 9.2. MPO plays an important role in neutrophil microbicidal action through catalyzing chloride ion oxidation to hypochlorous acid, which is a potent antimicrobial agent.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Hu01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
APA601Hu61 Active Myeloperoxidase (MPO) Cell culture; Activity Assays.
EPA601Hu61 Eukaryotic Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA601Hu02 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
APA601Hu02 Active Myeloperoxidase (MPO) Cell culture; Activity Assays.
Antibodies PAA601Hu01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Hu22 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
LAA601Hu71 Biotin-Linked Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC.
MAA601Hu21 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Hu23 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Hu24 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
Assay Kits SEA601Hu ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA601Hu CLIA Kit for Myeloperoxidase (MPO) Chemiluminescent immunoassay for Antigen Detection.
AEA601Hu ELISA Kit for Anti-Myeloperoxidase Antibody (Anti-MPO) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Mu01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA601Mu02 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA601Mu01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
PAA601Mu02 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
LAA601Mu71 Biotin-Linked Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC.
LAA601Mu81 FITC-Linked Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IF.
Assay Kits SEA601Mu ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA601Mu CLIA Kit for Myeloperoxidase (MPO) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Ra01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA601Ra02 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA601Ra01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Ra21 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
PAA601Ra02 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
Assay Kits SEA601Ra ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA601Ra CLIA Kit for Myeloperoxidase (MPO) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Po01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA601Po01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Po21 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
Assay Kits SEA601Po ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Bo01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
CPA601Bo21 OVA Conjugated Myeloperoxidase (MPO) Immunogen; SDS-PAGE; WB.
Antibodies PAA601Bo01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Bo21 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Bo22 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
Assay Kits SEA601Bo ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA601Eq01 Recombinant Myeloperoxidase (MPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA601Eq01 Polyclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
MAA601Eq21 Monoclonal Antibody to Myeloperoxidase (MPO) WB; IHC; ICC; IP.
Assay Kits SEA601Eq ELISA Kit for Myeloperoxidase (MPO) Enzyme-linked immunosorbent assay for Antigen Detection.
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  6. ErratumBiochemistry 27:9226-9226(1988)
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  11. "Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity."J. Biol. Chem. 285:16351-16359(2010) [PubMed] [Europe PMC] [Abstract]
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  14. "Isolation and characterization of a cDNA coding for human myeloperoxidase."Arch. Biochem. Biophys. 255:147-155(1987) [PubMed] [Europe PMC] [Abstract]
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  20. "Structure of the green heme in myeloperoxidase."Arch. Biochem. Biophys. 316:653-656(1995) [PubMed] [Europe PMC] [Abstract]
  21. "Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution."Biochemistry 40:13990-13997(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency."Blood 83:1935-1940(1994) [PubMed] [Europe PMC] [Abstract]
  23. "Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan."J. Biol. Chem. 269:1212-1216(1994) [PubMed] [Europe PMC] [Abstract]
  24. "Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase."J. Biol. Chem. 271:9546-9549(1996) [PubMed] [Europe PMC] [Abstract]
  25. "A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation."J. Clin. Invest. 101:2900-2909(1998) [PubMed] [Europe PMC] [Abstract]
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