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Granzyme B (GZMB)

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GZM-B; HLP; CTLA1; CCPI; CGL1; CSP-B; CSPB; CTSGL1; SECT; Granzyme 2; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Fragmentin 2; Cytotoxic Serine Protease B

Granzyme B (GZMB)
CCC A600
HGNC 4709
MGI 109267
PubMed 12752668
RGD 620018
UniProt P10144
Wiki Granzyme_B

Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Granzyme B is an important mediator of cytotoxic lymphocyte granule-induced death of target cells, accomplishing this through cleavage of Bid and cleavage and activation of caspases as well as direct cleavage of downstream substrates.

The serine proteinase GZMB is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. GZMB enters cells in a perforin-independent manner, predicting the existence of a cell surface receptor(s). Motyka et al. (2000) presented evidence that this receptor is the cation-independent mannose 6-phosphate receptor (CIMPR), also called IGF2R. Inhibition of the GZMB-IGF2R interaction prevented GZMB cell surface binding, uptake, and the induction of apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA600Hu01 Recombinant Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA600Hu01 Polyclonal Antibody to Granzyme B (GZMB) WB; IHC
MAA600Hu22 Monoclonal Antibody to Granzyme B (GZMB) WB
MAA600Hu21 Monoclonal Antibody to Granzyme B (GZMB) WB
Assay Kits SEA600Hu ELISA Kit for Granzyme B (GZMB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA600Mu01 Recombinant Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
RPA600Mu02 Recombinant Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA600Mu01 Polyclonal Antibody to Granzyme B (GZMB) WB; IHC; ICC; IP.
PAA600Mu02 Polyclonal Antibody to Granzyme B (GZMB) WB; IHC; ICC; IP.
Assay Kits SEA600Mu ELISA Kit for Granzyme B (GZMB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA600Ra01 Recombinant Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
EPA600Ra62 Eukaryotic Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA600Ra01 Polyclonal Antibody to Granzyme B (GZMB) WB; IHC; ICC; IP.
MAA600Ra21 Monoclonal Antibody to Granzyme B (GZMB) WB; IHC; ICC; IP.
Assay Kits SEA600Ra ELISA Kit for Granzyme B (GZMB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA600Po01 Recombinant Granzyme B (GZMB) Positive Control; Immunogen; SDS-PAGE; WB.
APA600Po01 Active Granzyme B (GZMB) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Granzyme B (GZMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Granzyme B (GZMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Granzyme B (GZMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme B (GZMB) ELISA Kit Customized Service Offer
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  12. "Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes."J. Immunol. 151:7161-7171(1993) [PubMed] [Europe PMC] [Abstract]
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  14. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue."Biol. Chem. 381:1203-1214(2000) [PubMed] [Europe PMC] [Abstract]
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  17. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]