Pyruvate kinase isozymes M2 (PKM2)

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M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein; Pyruvate Kinase, Muscle

Pyruvate kinase isozymes M2 (PKM2)

Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results.

M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Hu01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Hu02 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
APA588Hu02 Active Pyruvate kinase isozymes M2 (PKM2) Cell culture; Activity Assays.
RPA588Hu03 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Hu01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB,IHC,ICC/IF; FCM
MAA588Hu22 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
PAA588Hu02 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; IF;FCM
PAA588Hu03 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu23 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu21 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu24 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
Assay Kits SEA588Hu ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Mu01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Mu02 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Mu03 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Mu01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
PAA588Mu02 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
Assay Kits SEA588Mu ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Ra01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Ra01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Ra21 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
Assay Kits SEA588Ra ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Hamster (Chinese hamster)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA588Ha21 OVA Conjugated Pyruvate kinase isozymes M2 (PKM2) Immunogen; SDS-PAGE; WB.
RPA588Ha01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Ha08 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB
Assay Kits n/a CLIA Kit for Pyruvate kinase isozymes M2 (PKM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) ELISA Kit Customized Service Offer
  1. "Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma."Gene 73:509-516(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase."Proc. Natl. Acad. Sci. U.S.A. 86:7861-7865(1989) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990)
  4. "Isolation and characterization of the human pyruvate kinase M gene."Eur. J. Biochem. 198:101-106(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]