Pyruvate kinase isozymes M2 (PKM2)

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M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein; Pyruvate Kinase, Muscle

Pyruvate kinase isozymes M2 (PKM2)

Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results.

M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Hu01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Hu02 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
APA588Hu02 Active Pyruvate kinase isozymes M2 (PKM2) Cell culture; Activity Assays.
RPA588Hu03 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Hu01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC/IF; FCM
MAA588Hu22 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB
PAA588Hu02 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC/IF; FCM
PAA588Hu03 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC/IF
MAA588Hu23 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; ICC/IF
MAA588Hu21 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB
MAA588Hu24 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB
Assay Kits SEA588Hu ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Mu01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Mu02 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Mu03 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Mu01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
PAA588Mu02 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
Assay Kits SEA588Mu ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA588Ra01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Ra01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC/IF; FCM
MAA588Ra21 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
Assay Kits SEA588Ra ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Hamster (Chinese hamster)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA588Ha21 OVA Conjugated Pyruvate kinase isozymes M2 (PKM2) Immunogen; SDS-PAGE; WB.
RPA588Ha01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA588Ha08 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB
Assay Kits n/a CLIA Kit for Pyruvate kinase isozymes M2 (PKM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) ELISA Kit Customized Service Offer
  1. "Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma."Gene 73:509-516(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase."Proc. Natl. Acad. Sci. U.S.A. 86:7861-7865(1989) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990)
  4. "Isolation and characterization of the human pyruvate kinase M gene."Eur. J. Biochem. 198:101-106(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]