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Thyroid Peroxidase (TPO)

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TPX; thyroperoxidase

Thyroid Peroxidase (TPO)
CCC A557
HGNC 12015
MGI 98813
PubMed 9360536
RGD 3900
UniProt P07202
Wiki TPO

Thyroid peroxidase is an enzyme normally found in the thyroid gland, which plays an important role in the production of thyroid hormones. Fabrication of thyroid hormones is conducted by the enzyme thyroid peroxidase, an integral membrane protein present in the apical (colloid-facing) plasma membrane of thyroid epithelial cells.

Thyroid peroxidase catalyzes two sequential reactions: Iodination of tyrosines on thyroglobulin  Synthesis of thyroxine or triiodothyronine from two iodotyrosines. Through the action of thyroid peroxidase, thyroid hormones accumulate in colloid, on the surface of thyroid epithelial cells. Remember that hormone is still tied up in molecules of thyroglobulin - the task remaining is to liberate it from the scaffold and secrete free hormone into blood.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA557Hu01 Recombinant Thyroid Peroxidase (TPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA557Hu01 Polyclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
MAA557Hu22 Monoclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
Assay Kits SEA557Hu ELISA Kit for Thyroid Peroxidase (TPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA557Mu01 Recombinant Thyroid Peroxidase (TPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA557Mu03 Recombinant Thyroid Peroxidase (TPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA557Mu02 Recombinant Thyroid Peroxidase (TPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA557Mu01 Polyclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
PAA557Mu02 Polyclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
LAA557Mu71 Biotin-Linked Polyclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Thyroid Peroxidase (TPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroid Peroxidase (TPO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA557Ra01 Recombinant Thyroid Peroxidase (TPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA557Ra01 Polyclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
MAA557Ra21 Monoclonal Antibody to Thyroid Peroxidase (TPO) WB; IHC; ICC; IP.
Assay Kits SEA557Ra ELISA Kit for Thyroid Peroxidase (TPO) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA557Ra ELISA Kit for Anti-Thyroid Peroxidase Antibody (Anti-TPO) Enzyme-linked immunosorbent assay for Antibody Detection.
  1. "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs."Proc. Natl. Acad. Sci. U.S.A. 84:5555-5559(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA."Nucleic Acids Res. 15:6735-6735(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene."Biochemistry 28:4481-4489(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2."Nucleic Acids Res. 18:670-670(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs."J. Biol. Chem. 278:3793-3800(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase."J. Clin. Invest. 80:1205-1208(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence for an alternate splicing in the thyroperoxidase messenger from patients with Graves' disease."Biochem. Biophys. Res. Commun. 170:735-741(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis."Hum. Mutat. 6:9-16(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects."J. Clin. Endocrinol. Metab. 82:649-653(1997) [PubMed] [Europe PMC] [Abstract]
  11. "A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect."Clin. Endocrinol. (Oxf.) 51:165-172(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping."J. Clin. Endocrinol. Metab. 84:1061-1071(1999) [PubMed] [Europe PMC] [Abstract]
  13. "A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect."J. Endocrinol. 160:267-273(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update)."J. Clin. Endocrinol. Metab. 85:3708-3712(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism."Eur. J. Endocrinol. 145:19-24(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism."Eur. J. Endocrinol. 146:491-498(2002) [PubMed] [Europe PMC] [Abstract]
  17. "High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect."J. Clin. Endocrinol. Metab. 87:4208-4212(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations."J. Endocrinol. 172:627-635(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach."Thyroid 12:945-951(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings."Clin. Endocrinol. (Oxf.) 59:198-206(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect."Hum. Mutat. 22:259-259(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect."J. Clin. Endocrinol. Metab. 88:3264-3271(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism."Endocr. J. 52:643-645(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes."J. Clin. Endocrinol. Metab. 91:2678-2681(2006) [PubMed] [Europe PMC] [Abstract]