Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)
[Edit]EPO; CLGI; EPA; HCI; Erythroid Potentiating Activity; Collagenase Inhibitor; Metalloproteinase inhibitor 1; Fibroblast collagenase inhibitor
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TIMP metallopeptidase inhibitor 1, a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Mu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA552Mu02 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA552Mu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| LAA552Mu71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC. | |
| PAA552Mu02 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA552Mu | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA552Mu | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Rb01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA552Rb02 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA552Rb52 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| PAA552Rb51 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| LAA552Rb71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC. | |
| LAA552Rb81 | FITC-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IF. | |
| Assay Kits | SEA552Rb | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Ca01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA552Ca01 | Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA552Ca01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| LAA552Ca71 | Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC. | |
| MAA552Ca21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA552Ca | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Po01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA552Po01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| MAA552Po21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA552Po | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Bo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA552Bo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| MAA552Bo21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA552Bo | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Ov01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA552Ov01 | Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA552Ov01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| Assay Kits | SEA552Ov | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA552Eq01 | Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA552Eq01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. |
| MAA552Eq21 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA552Eq | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function."Biochemistry 49:6184-6192(2010) [PubMed] [Europe PMC] [Abstract]
- "Matrix metalloproteinase-10 (MMP10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure."J. Biol. Chem. 287:15935-15946(2012) [PubMed] [Europe PMC] [Abstract]