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Fibroblast Growth Factor 2, Basic (FGF2)

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B-FGF; BFGF; FGFB; HBGH-2; Basic Fibroblast Growth Factor; Heparin-binding growth factor 2

Fibroblast Growth Factor 2, Basic (FGF2)
CCC A551
HGNC 3676
MGI 95516
PubMed 9742155
RGD 2609
UniProt P09038
Wiki BFGF

FGF basic is one of at least 22 mitogenic proteins of the FGF family, which show 35 - 60% amino acid conservation.Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell surface heparan sulfate proteoglycans (HSPG) are likely. The predicted 18 kDa FGF basic isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form secreted. Transcription from alternate start sites produces 21 - 23 kDa forms found only in the nucleus. High and low molecular weight human FGF basic targets the expression of different genes when expressed in NIH-3T3 cells.The 18 kDa rat sequence has 98% aa identity with mouse, and 96 - 97% identity with human, bovine and sheep FGF basic.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Hu01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
CPA551Hu21 OVA Conjugated Fibroblast Growth Factor 2, Basic (FGF2) Immunogen; SDS-PAGE; WB.
APA551Hu01 Active Fibroblast Growth Factor 2, Basic (FGF2) Cell culture; Activity Assays.
RPA551Hu02 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA551Hu04 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA551Hu01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
MAA551Hu22 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
LAA551Hu71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC.
LAA551Hu81 FITC-Linked Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IF.
MAA551Hu21 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits CEA551Hu ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA551Hu ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA551Hu High Sensitive ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Mu01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA551Mu02 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA551Mu01 Active Fibroblast Growth Factor 2, Basic (FGF2) Cell culture; Activity Assays.
Antibodies PAA551Mu01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
PAA551Mu02 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits CEA551Mu ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA551Mu ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Ra01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA551Ra01 Active Fibroblast Growth Factor 2, Basic (FGF2) Cell culture; Activity Assays.
Antibodies PAA551Ra01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
MAA551Ra21 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits CEA551Ra ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA551Ra ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Rb01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA551Rb02 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA551Rb52 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
PAA551Rb51 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
PAA551Rb01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits SEA551Rb ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Po01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA551Po01 Active Fibroblast Growth Factor 2, Basic (FGF2) Cell culture; Activity Assays.
Antibodies PAA551Po01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
MAA551Po21 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits CEA551Po ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Bo01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
APA551Bo01 Active Fibroblast Growth Factor 2, Basic (FGF2) Cell culture; Activity Assays.
Antibodies PAA551Bo01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
MAA551Bo21 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits CEA551Bo ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA551Ga01 Recombinant Fibroblast Growth Factor 2, Basic (FGF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA551Ga01 Polyclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
MAA551Ga21 Monoclonal Antibody to Fibroblast Growth Factor 2, Basic (FGF2) WB; IHC; ICC; IP.
Assay Kits SEA551Ga ELISA Kit for Fibroblast Growth Factor 2, Basic (FGF2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells."Cold Spring Harb. Symp. Quant. Biol. 51:657-668(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human basic fibroblast growth factor: nucleotide sequence and genomic organization."EMBO J. 5:2523-2528(1986) [PubMed] [Europe PMC] [Abstract]
  3. "High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons."Proc. Natl. Acad. Sci. U.S.A. 86:1836-1840(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Basic fibroblast growth factor gene expression."Ann. N. Y. Acad. Sci. 638:109-126(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and expression of cDNA encoding human basic fibroblast growth factor."FEBS Lett. 213:189-194(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis."Jpn. J. Cancer Res. 82:1263-1270(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor."Cancer Res. 56:633-636(1996) [PubMed] [Europe PMC] [Abstract]
  10. "A form of human basic fibroblast growth factor with an extended amino terminus."Biochem. Biophys. Res. Commun. 144:543-550(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue."Biochem. Biophys. Res. Commun. 142:702-709(1987) [PubMed] [Europe PMC] [Abstract]
  12. "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities."Biochem. Biophys. Res. Commun. 135:541-548(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors."FEBS Lett. 204:203-207(1986) [PubMed] [Europe PMC] [Abstract]
  14. "Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients."Biochem. Biophys. Res. Commun. 187:1227-1231(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  17. "High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan."J. Biol. Chem. 274:16831-16837(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion."Traffic 11:813-826(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Cellular signaling by fibroblast growth factor receptors."Cytokine Growth Factor Rev. 16:139-149(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of basic fibroblast growth factor at 1.6-A resolution."J. Biochem. 110:360-363(1991) [PubMed] [Europe PMC] [Abstract]
  26. "Three-dimensional structure of human basic fibroblast growth factor."Proc. Natl. Acad. Sci. U.S.A. 88:3441-3445(1991) [PubMed] [Europe PMC] [Abstract]
  27. "Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta."Proc. Natl. Acad. Sci. U.S.A. 88:3446-3450(1991) [PubMed] [Europe PMC] [Abstract]
  28. "Three-dimensional structures of acidic and basic fibroblast growth factors."Science 251:90-93(1991) [PubMed] [Europe PMC] [Abstract]
  29. "Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution."Protein Sci. 2:1274-1284(1993) [PubMed] [Europe PMC] [Abstract]
  30. "Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome."Proc. Natl. Acad. Sci. U.S.A. 98:7182-7187(2001) [PubMed] [Europe PMC] [Abstract]
  31. "High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy."Biochemistry 35:13552-13561(1996) [PubMed] [Europe PMC] [Abstract]