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Keratin 2 (CK2)

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KRT2A; KRT2; KRTE; Keratin 2; Keratin 2A; Keratin 2E; Epidermal Ichthyosis Bullosa Of Siemens; Keratin, type II cytoskeletal 2 epidermal; Epithelial keratin-2e

Keratin 2 (CK2)
CCC A491
HGNC 6439
MGI 96699
PubMed 20456496
RGD 1303297
UniProt P35908
Wiki Keratin_2

Keratin 2A is a type II cytokeratin, also known as Keratin 2E or Keratin 2. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2 is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner. The other major epidermal keratins, KRT6 and KRT16, are normally expressed in the outer root sheath of the hair follicle and in palmoplantar epidermis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA491Hu01 Recombinant Keratin 2 (CK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA491Hu01 Polyclonal Antibody to Keratin 2 (CK2) WB; IHC; ICC; IP.
MAA491Hu22 Monoclonal Antibody to Keratin 2 (CK2) WB; IHC; ICC; IP.
MAA491Hu21 Monoclonal Antibody to Keratin 2 (CK2) WB
Assay Kits SEA491Hu ELISA Kit for Keratin 2 (CK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA491Mu01 Recombinant Keratin 2 (CK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA491Mu01 Polyclonal Antibody to Keratin 2 (CK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Keratin 2 (CK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 2 (CK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA491Ra01 Recombinant Keratin 2 (CK2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA491Ra02 Recombinant Keratin 2 (CK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA491Ra01 Polyclonal Antibody to Keratin 2 (CK2) WB; IHC; ICC; IP.
PAA491Ra02 Polyclonal Antibody to Keratin 2 (CK2) WB
LAA491Ra71 Biotin-Linked Polyclonal Antibody to Keratin 2 (CK2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Keratin 2 (CK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 2 (CK2) ELISA Kit Customized Service Offer
  1. "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation."Exp. Cell Res. 202:132-141(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens."J. Invest. Dermatol. 111:817-821(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development."Br. J. Dermatol. 140:582-591(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization."Am. J. Pathol. 162:963-975(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Ichthyosis bullosa of Siemens -- a disease involving keratin 2e."J. Invest. Dermatol. 103:277-281(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene."J. Invest. Dermatol. 103:286-289(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens."Nat. Genet. 7:485-490(1994) [PubMed] [Europe PMC] [Abstract]
  13. "A new keratin 2e mutation in ichthyosis bullosa of Siemens."J. Invest. Dermatol. 108:354-356(1997) [PubMed] [Europe PMC] [Abstract]
  14. "A novel threonine-to-proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens."J. Invest. Dermatol. 109:116-118(1997) [PubMed] [Europe PMC] [Abstract]
  15. "A glutamate to lysine mutation at the end of 2B rod domain of keratin 2e gene in ichthyosis bullosa of Siemens."Acta Derm. Venereol. 78:417-419(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Ichthyosis bullosa of Siemens: report of a family with evidence of a keratin 2e mutation, and a review of the literature."Br. J. Dermatol. 140:689-695(1999) [PubMed] [Europe PMC] [Abstract]
  17. "A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens."J. Invest. Dermatol. 112:380-382(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Ichthyosis bullosa of Siemens resulting from a novel missense mutation near the helix termination motif of the keratin 2e gene."Clin. Exp. Dermatol. 24:412-415(1999) [PubMed] [Europe PMC] [Abstract]
  19. "A novel mutation in the 2B domain of keratin 2e causing ichthyosis bullosa of Siemens."Clin. Exp. Dermatol. 25:648-651(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens."Exp. Dermatol. 9:11-15(2000) [PubMed] [Europe PMC] [Abstract]
  21. "A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens."J. Invest. Dermatol. 114:193-195(2000) [PubMed] [Europe PMC] [Abstract]
  22. "New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens."Br. J. Dermatol. 145:330-335(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing."Br. J. Dermatol. 152:1353-1356(2005) [PubMed] [Europe PMC] [Abstract]