Follistatin (FS)

Follistatin was first identified as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. It has since been shown to be a multifunctional regulatory protein exerting a majority of its effects via neutralization of activin. FS is a monomeric binding protein that regulates activin activity by forming an inactive complex. FS plays a role as a tissue regulator in the gonad, pituitary gland,pregnancy membranes, vasculature, and liver. It is also essential for normal development, as FS-knockout mice die shortly after birth with a range of defects including insufficient muscle development and skeletal abnormalities. Alternative splicing events, proteolytic cleavage and variable glycosylation lead to a vast array of possible FS isoforms found within various biological fluids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Hu01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Hu01 Polyclonal Antibody to Follistatin (FS) WB; IHC
MAA391Hu22 Monoclonal Antibody to Follistatin (FS) WB
MAA391Hu21 Monoclonal Antibody to Follistatin (FS) WB
MAA391Hu23 Monoclonal Antibody to Follistatin (FS) WB
MAA391Hu24 Monoclonal Antibody to Follistatin (FS) WB
Assay Kits SEA391Hu ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Mu01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
RPA391Mu02 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Mu01 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
PAA391Mu02 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
Assay Kits CEA391Mu ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA391Ra01 Recombinant Follistatin (FS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA391Ra01 Polyclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
MAA391Ra21 Monoclonal Antibody to Follistatin (FS) WB; IHC; ICC; IP.
Assay Kits CEA391Ra ELISA Kit for Follistatin (FS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of the human follistatin precursor and its genomic organization."Proc. Natl. Acad. Sci. U.S.A. 85:4218-4222(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay."J. Clin. Endocrinol. Metab. 89:5067-5075(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding."Dev. Cell 9:535-543(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions."J. Biol. Chem. 282:15930-15939(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding."EMBO J. 28:2662-2676(2009) [PubMed] [Europe PMC] [Abstract]
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