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GATA Binding Protein 1 (GATA1)

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ERYF1; GF1; NFE1; Globin Transcription Factor 1; Erythroid transcription factor; ; NF-E1 DNA-binding protein

GATA Binding Protein 1 (GATA1)
CCC A336
HGNC 4170
MGI 95661
PubMed 12832487
RGD 2663
UniProt P15976
Wiki GATA1

GATA1 is an important transcription factor involved in cell growth and cancer.The protein belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

It is essential for erythroid (red blood cell) and megakaryocytic (platelet producing cell) development and mice without GATA1 die as embryos. It helps transcribe the α-spectrin structural protein which is critical for the shape of red blood cells.It has been found to enhance the transcription rates by up to 100 times in humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA336Hu01 Recombinant GATA Binding Protein 1 (GATA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA336Hu01 Polyclonal Antibody to GATA Binding Protein 1 (GATA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 1 (GATA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 1 (GATA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA336Mu01 Recombinant GATA Binding Protein 1 (GATA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA336Mu01 Polyclonal Antibody to GATA Binding Protein 1 (GATA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 1 (GATA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 1 (GATA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA336Ra01 Recombinant GATA Binding Protein 1 (GATA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA336Ra01 Polyclonal Antibody to GATA Binding Protein 1 (GATA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 1 (GATA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 1 (GATA1) ELISA Kit Customized Service Offer
  1. "Structure and evolution of a human erythroid transcription factor."Nature 343:92-96(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome."Proc. Natl. Acad. Sci. U.S.A. 87:668-672(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor."Proc. Natl. Acad. Sci. U.S.A. 92:11598-11602(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of activity of the transcription factor GATA-1 by acetylation."Nature 396:594-598(1998) [PubMed] [Europe PMC] [Abstract]
  7. "An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis."Nat. Genet. 38:807-812(2006) [PubMed] [Europe PMC] [Abstract]
  8. "PDSM, a motif for phosphorylation-dependent SUMO modification."Proc. Natl. Acad. Sci. U.S.A. 103:45-50(2006) [PubMed] [Europe PMC] [Abstract]
  9. "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription."Mol. Cell. Biol. 27:4261-4272(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells."PLoS ONE 7:E29518-E29518(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1."Nat. Genet. 24:266-270(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation."Blood 98:85-92(2001) [PubMed] [Europe PMC] [Abstract]
  13. "X-linked thrombocytopenia caused by a novel mutation of GATA-1."Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  14. "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction."Blood 100:2040-2045(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation."Hum. Mol. Genet. 11:147-152(2002) [PubMed] [Europe PMC] [Abstract]