Annexin V (ANXA5)

[Edit]

ANX5; ENX2; PP4; PAP-I; CBP-I; Anchorin CII; Calphobindin I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; Thromboplastin inhibitor; Vascular anticoagulant-alpha

Annexin V (ANXA5)

(or annexin V) is a cellular protein in the annexin group. The function of the protein is unknown, however annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments. Antibodies directed against annexin A5 are the cause of a syndrome called the antiphospholipid syndrome. Annexin A5 is used as a probe in the annexin A5 affinity assay to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis as well as other forms of cell death. Platelets also expose phosphatidylserine on their surface when activated, which serves as binding site for various coagulation factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Hu01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA259Hu02 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
EPA259Hu61 Eukaryotic Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA259Hu03 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA259Hu04 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
APA259Hu61 Active Annexin V (ANXA5) Cell culture; Activity Assays.
RPA259Hu05 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA259Hu06 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
APA259Hu01 Active Annexin V (ANXA5) Cell culture; Activity Assays.
APA259Hu02 Active Annexin V (ANXA5) Cell culture; Activity Assays.
APA259Hu03 Active Annexin V (ANXA5) Cell culture; Activity Assays.
APA259Hu06 Active Annexin V (ANXA5) Cell culture; Activity Assays.
Antibodies PAA259Hu01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
MAA259Hu22 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC
LAA259Hu82 FITC-Linked Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
LAA259Hu72 Biotin-Linked Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Hu71 Biotin-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Hu81 FITC-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
MAA259Hu21 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
MAA259Hu23 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
MAA259Hu24 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
Assay Kits SEA259Hu ELISA Kit for Annexin V (ANXA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Mu01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA259Mu02 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
APA259Mu01 Active Annexin V (ANXA5) Cell culture; Activity Assays.
Antibodies PAA259Mu01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
LAA259Mu71 Biotin-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Mu81 FITC-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
PAA259Mu02 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
Assay Kits SEA259Mu ELISA Kit for Annexin V (ANXA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Ra01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
APA259Ra01 Active Annexin V (ANXA5) Cell culture; Activity Assays.
Antibodies PAA259Ra01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
LAA259Ra71 Biotin-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Ra81 FITC-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
MAA259Ra21 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
Assay Kits SEA259Ra ELISA Kit for Annexin V (ANXA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Si01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA259Si01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
MAA259Si21 Monoclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
Assay Kits SEA259Si ELISA Kit for Annexin V (ANXA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Bo01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA259Bo01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
LAA259Bo71 Biotin-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Bo81 FITC-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Annexin V (ANXA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Annexin V (ANXA5) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA259Ga01 Recombinant Annexin V (ANXA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA259Ga01 Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IP.
LAA259Ga71 Biotin-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC.
LAA259Ga81 FITC-Linked Polyclonal Antibody to Annexin V (ANXA5) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Annexin V (ANXA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Annexin V (ANXA5) ELISA Kit Customized Service Offer
  1. "Primary structure of human placental anticoagulant protein."Biochemistry 26:8087-8092(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein."J. Biochem. 102:1261-1273(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein."Eur. J. Biochem. 174:585-592(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein."J. Biol. Chem. 263:8037-8043(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I."J. Biol. Chem. 263:10799-10811(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family."Proc. Natl. Acad. Sci. U.S.A. 85:3708-3712(1988) [PubMed] [Europe PMC] [Abstract]
  7. "The gene encoding human annexin V has a TATA-less promoter with a high G+C content."Gene 149:253-260(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Organization of the human annexin V (ANX5) gene."Genomics 20:463-467(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation."Biochem. J. 263:929-935(1989) [PubMed] [Europe PMC] [Abstract]
  13. , Submitted (JAN-2005) to UniProtKB
  14. "Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein."Virology 197:549-557(1993) [PubMed] [Europe PMC] [Abstract]
  15. "Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein."Proc. Natl. Acad. Sci. U.S.A. 84:6078-6082(1987) [PubMed] [Europe PMC] [Abstract]
  16. "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor."J. Biol. Chem. 263:18657-18663(1988) [PubMed] [Europe PMC] [Abstract]
  17. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."Mol. Cell 23:607-618(2006) [PubMed] [Europe PMC] [Abstract]
  19. "A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss."Hum. Mol. Genet. 16:573-578(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Target-selective protein S-nitrosylation by sequence motif recognition."Cell 159:623-634(2014) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes."EMBO J. 9:3867-3874(1990) [PubMed] [Europe PMC] [Abstract]
  26. "The calcium binding sites in human annexin V by crystal structure analysis at 2.0-A resolution. Implications for membrane binding and calcium channel activity."FEBS Lett. 275:15-21(1990) [PubMed] [Europe PMC] [Abstract]
  27. "Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins."J. Mol. Biol. 223:683-704(1992) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor."J. Mol. Biol. 274:16-20(1997) [PubMed] [Europe PMC] [Abstract]
  29. "Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V."Proc. Natl. Acad. Sci. U.S.A. 95:455-459(1998) [PubMed] [Europe PMC] [Abstract]