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Prostatic Acid Phosphatase (PAP)

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PSAP; ACPP; ACP3; PAPf39; 5'-NT; Prostatic Specific Acid Phosphatase; Ecto-5'-Nucleotidase

Prostatic Acid Phosphatase (PAP)
CCC A168
HGNC 125
MGI 1928480
PubMed 6995224
RGD 2023
UniProt P15309
Wiki ACP3

Prostatic acid phosphatase (PAP) is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases.The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the level.Its physiological function may be associated with the liquefaction process of semen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA168Hu01 Recombinant Prostatic Acid Phosphatase (PAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA168Hu01 Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC; IP.
MAA168Hu22 Monoclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC; IP.
LAA168Hu71 Biotin-Linked Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC.
PAA168Hu02 Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC; IP.
Assay Kits SEA168Hu ELISA Kit for Prostatic Acid Phosphatase (PAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA168Mu01 Recombinant Prostatic Acid Phosphatase (PAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA168Mu01 Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC; IP.
LAA168Mu71 Biotin-Linked Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Prostatic Acid Phosphatase (PAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostatic Acid Phosphatase (PAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA168Ra01 Recombinant Prostatic Acid Phosphatase (PAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Prostatic Acid Phosphatase (PAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostatic Acid Phosphatase (PAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostatic Acid Phosphatase (PAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostatic Acid Phosphatase (PAP) ELISA Kit Customized Service Offer
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  8. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy."Arch. Biochem. Biophys. 258:404-412(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase."Acta Biochim. Pol. 44:659-672(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma."FEBS Lett. 571:197-204(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Prostatic acid phosphatase is not a prostate specific target."Cancer Res. 67:6549-6554(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Semen-derived amyloid fibrils drastically enhance HIV infection." Cell 131:1059-1071(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Integral and associated lysosomal membrane proteins."Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer."J. Virol. 83:6995-7003(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection."Proc. Natl. Acad. Sci. U.S.A. 106:9033-9038(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection)."J. Biol. Chem. 285:1861-1869(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth."J. Biol. Chem. 285:23598-23606(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Prostatic acid phosphatase expression in human tissues."Int. J. Clin. Exp. Pathol. 4:295-306(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase."J. Biol. Chem. 273:30406-30409(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of human prostatic acid phosphatase."Prostate 42:211-218(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design."Biochemistry 42:383-389(2003) [PubMed] [Europe PMC] [Abstract]
  24. "NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286)."J. Am. Chem. Soc. 131:17972-17979(2009) [PubMed] [Europe PMC] [Abstract]