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Collagen Type IV Alpha 1 (COL4a1)

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COL4-A1; Arresten; Collagen Alpha-1(IV)chain

Collagen Type IV Alpha 1 (COL4a1)
CCC A149
HGNC 2202
MGI 88454
PubMed 22522439
RGD 1307148
UniProt P02462
Wiki COL4A1
Collagen, type IV, alpha 1 is a major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.Types I, II, and III collagen, the so-called interstitial collagens, are in many ways distinct from basement membrane collagen. Type IV collagen does not form ordered fibrillar structures; rather, a meshwork is formed by 4 molecules held together at the ends. Both disulfide and typical lysyl-derived collagen crosslinks are involved. The collagen IV molecule is a heterotrimer of 2 alpha-1 chains and 1 alpha-2 chain. The alpha-2 chain is encoded at a distinct locus (COL4A2).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA149Hu01 Recombinant Collagen Type IV Alpha 1 (COL4a1) Positive Control; Immunogen; SDS-PAGE; WB.
APA149Hu01 Active Collagen Type IV Alpha 1 (COL4a1) Cell culture; Activity Assays.
Antibodies PAA149Hu01 Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
MAA149Hu22 Monoclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
LAA149Hu71 Biotin-Linked Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC.
LAA149Hu81 FITC-Linked Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IF.
MAA149Hu21 Monoclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
Assay Kits SEA149Hu ELISA Kit for Collagen Type IV Alpha 1 (COL4a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA149Mu01 Recombinant Collagen Type IV Alpha 1 (COL4a1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA149Mu02 Recombinant Collagen Type IV Alpha 1 (COL4a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA149Mu01 Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
PAA149Mu02 Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
Assay Kits SEA149Mu ELISA Kit for Collagen Type IV Alpha 1 (COL4a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA149Ra01 Recombinant Collagen Type IV Alpha 1 (COL4a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA149Ra01 Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
MAA149Ra21 Monoclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) WB; IHC; ICC; IP.
Assay Kits SEA149Ra ELISA Kit for Collagen Type IV Alpha 1 (COL4a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA149Bo01 Recombinant Collagen Type IV Alpha 1 (COL4a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type IV Alpha 1 (COL4a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type IV Alpha 1 (COL4a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type IV Alpha 1 (COL4a1) ELISA Kit Customized Service Offer
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  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link."Proc. Natl. Acad. Sci. U.S.A. 99:6607-6612(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly."Science 308:1167-1171(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly."J. Med. Genet. 43:490-495(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Role of COL4A1 in small-vessel disease and hemorrhagic stroke."N. Engl. J. Med. 354:1489-1496(2006) [PubMed] [Europe PMC] [Abstract]
  22. "COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke."Ann. Neurol. 62:177-184(2007) [PubMed] [Europe PMC] [Abstract]
  23. "COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps."N. Engl. J. Med. 357:2687-2695(2007) [PubMed] [Europe PMC] [Abstract]
  24. "A sulfilimine bond identified in collagen IV."Science 325:1230-1234(2009) [PubMed] [Europe PMC] [Abstract]
  25. "COL4A1 mutation in a patient with sporadic, recurrent intracerebral hemorrhage."Stroke 38:1461-1464(2007) [PubMed] [Europe PMC] [Abstract]
  26. "COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage."Ann. Neurol. 65:12-18(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain."Am. J. Med. Genet. A 152:2550-2555(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Ophthalmological features associated with COL4A1 mutations."Arch. Ophthalmol. 128:483-489(2010) [PubMed] [Europe PMC] [Abstract]
  29. "A dominantly inherited mutation in collagen IV A1 (COL4A1) causing childhood onset stroke without porencephaly."Eur. J. Paediatr. Neurol. 14:182-187(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus."Mol. Vis. 17:827-843(2011) [PubMed] [Europe PMC] [Abstract]