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Plasminogen Activator, Urokinase Receptor (uPAR)

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CD87; PLAUR; PLAU-R; U-PAR; URKR; Monocyte Activation Antigen Mo3

Plasminogen Activator, Urokinase Receptor (uPAR)
CCC A141
HGNC 9053
MGI 97612
PubMed 12461559
RGD 620597
UniProt Q03405
Wiki UPAR

uPAR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. All three domains are necessary for high affinity binding of the primary ligand, urokinase. It has been possible to express uPAR recombinantly in CHO-cells and S2 cells. 4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50-60 kDA. Recently the structure of uPAR was solved by X-ray crystallography in complex with an peptide antagonist and with its native ligand, urokinase.However the components of the plasminogen activation system have been found to be highly expressed in many malignant tumors, indicating that tumors are able to hijack the system, and use it in metastasis. Thus inhibitors of the various components of the plasminogen activation system has been sought as possible anticancer drugs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA141Hu01 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA141Hu02 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA141Hu03 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA141Hu04 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
APA141Hu04 Active Plasminogen Activator, Urokinase Receptor (uPAR) Cell culture; Activity Assays.
Antibodies PAA141Hu01 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
MAA141Hu22 Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
PAA141Hu02 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
PAA141Hu03 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
LAA141Hu71 Biotin-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC.
LAA141Hu81 FITC-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IF.
MAA141Hu21 Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
LAA141Hu82 FITC-Linked Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IF.
LAA141Hu83 FITC-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IF.
PAA141Hu04 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB
Assay Kits SEA141Hu ELISA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA141Mu01 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA141Mu02 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
APA141Mu01 Active Plasminogen Activator, Urokinase Receptor (uPAR) Cell culture; Activity Assays.
Antibodies PAA141Mu01 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
LAA141Mu71 Biotin-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC.
LAA141Mu81 FITC-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IF.
PAA141Mu02 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
Assay Kits SEA141Mu ELISA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA141Ra01 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
APA141Ra01 Active Plasminogen Activator, Urokinase Receptor (uPAR) Cell culture; Activity Assays.
Antibodies PAA141Ra01 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
LAA141Ra71 Biotin-Linked Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC.
MAA141Ra21 Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
MAA141Ra22 Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
MAA141Ra23 Monoclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
Assay Kits SEA141Ra ELISA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA141Si01 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA141Si01 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA141Bo01 Recombinant Plasminogen Activator, Urokinase Receptor (uPAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA141Bo01 Polyclonal Antibody to Plasminogen Activator, Urokinase Receptor (uPAR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plasminogen Activator, Urokinase Receptor (uPAR) ELISA Kit Customized Service Offer
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  11. "The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants."J. Biol. Chem. 265:6453-6460(1990) [PubMed] [Europe PMC] [Abstract]
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  13. "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)."J. Biol. Chem. 270:14107-14114(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins."J. Biol. Chem. 268:17539-17546(1993) [PubMed] [Europe PMC] [Abstract]
  15. "A urokinase receptor-associated protein with specific collagen binding properties."J. Biol. Chem. 275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton."Carcinogenesis 23:1593-1601(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]
  18. "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."Circ. Res. 94:752-758(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."Hum. Mol. Genet. 17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide."EMBO J. 24:1655-1663(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of human urokinase plasminogen activator in complex with its receptor."Science 311:656-659(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of the urokinase receptor in a ligand-free form."J. Mol. Biol. 416:629-641(2012) [PubMed] [Europe PMC] [Abstract]