Tumor Necrosis Factor Beta (TNFb)
[Edit]LT; LTA; TNF-B; TNFSF1; Tumor Necrosis Factor Ligand Superfamily Member 1; Lymphotoxin Alpha
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TNF-beta is a potent mediator of inflammatory and immune responses.TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Hu01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA134Hu01 | Active Tumor Necrosis Factor Beta (TNFb) | Cell culture; Activity Assays. | |
| Antibodies | PAA134Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| MAA134Hu22 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| MAA134Hu21 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA134Hu | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Mu01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA134Mu02 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA134Mu01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| PAA134Mu02 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| LAA134Mu71 | Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC. | |
| Assay Kits | SEA134Mu | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Ra01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA134Ra02 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA134Ra02 | Active Tumor Necrosis Factor Beta (TNFb) | Cell culture; Activity Assays. | |
| Antibodies | PAA134Ra01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| MAA134Ra21 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| PAA134Ra02 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA134Ra | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Rb01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA134Rb51 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| MAA134Rb21 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| PAA134Rb01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA134Rb | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Si01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA134Si01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Tumor Necrosis Factor Beta (TNFb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Ca01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA134Ca01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| LAA134Ca71 | Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Tumor Necrosis Factor Beta (TNFb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Po01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA134Po01 | Active Tumor Necrosis Factor Beta (TNFb) | Cell culture; Activity Assays. | |
| Antibodies | PAA134Po01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| MAA134Po21 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA134Po | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA134Bo01 | Recombinant Tumor Necrosis Factor Beta (TNFb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA134Bo01 | Polyclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. |
| MAA134Bo21 | Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA134Bo | ELISA Kit for Tumor Necrosis Factor Beta (TNFb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome."Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986) [PubMed] [Europe PMC] [Abstract]
- "Structure and chromosomal localization of the human lymphotoxin gene."J. Cell. Biochem. 29:171-181(1985) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma."J. Biochem. 100:727-733(1986) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity."Nature 312:721-724(1984) [PubMed] [Europe PMC] [Abstract]
- "Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788."FEBS Lett. 302:141-144(1992) [PubMed] [Europe PMC] [Abstract]
- "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract]
- "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
- "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation."FEBS Lett. 314:85-88(1992) [PubMed] [Europe PMC] [Abstract]
- "The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution."J. Biol. Chem. 267:2119-2122(1992) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."Cell 73:431-445(1993) [PubMed] [Europe PMC] [Abstract]
- "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production."J. Exp. Med. 173:209-219(1991) [PubMed] [Europe PMC] [Abstract]
- "Haplotypic polymorphisms of the TNFB gene."Immunogenetics 33:50-53(1991) [PubMed] [Europe PMC] [Abstract]
- "Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity."Arthritis Rheum. 48:1408-1413(2003) [PubMed] [Europe PMC] [Abstract]
- "Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy."Nat. Genet. 39:517-522(2007) [PubMed] [Europe PMC] [Abstract]