Macrophage Inflammatory Protein 3 Alpha (MIP3a)
[Edit]CCL20; CKb4; LARC; MIP3-A; SCYA20; ST38; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 20; Beta-Chemokine Exodus-1; Liver And Activation-Regulated Chemokine
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Chemokine (C-C motif) ligand 20 is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.
CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.CCL20 can be induced by microbial factors such as lipopolysaccharide, and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA095Mu01 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA095Mu02 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA095Mu01 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. |
| LAA095Mu71 | Biotin-Linked Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC. | |
| PAA095Mu02 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA095Mu | ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA095Ra01 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA095Ra01 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. |
| MAA095Ra21 | Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. | |
| MAA095Ra22 | Monoclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA095Ra | ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA095Ra | CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA095Ca01 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA095Ca01 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA095Po01 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA095Po01 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. |
| Assay Kits | SEA095Po | ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA095Bo01 | Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA095Bo01 | Polyclonal Antibody to Macrophage Inflammatory Protein 3 Alpha (MIP3a) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a) | ELISA Kit Customized Service Offer |
- "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta."J. Immunol. 158:1033-1036(1997) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2."J. Biol. Chem. 272:5846-5853(1997) [PubMed] [Europe PMC] [Abstract]
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- "Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization."Genomics 73:28-37(2001) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells."J. Immunol. 165:4470-4477(2000) [PubMed] [Europe PMC] [Abstract]
- "The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins."J. Biol. Chem. 277:37647-37654(2002) [PubMed] [Europe PMC] [Abstract]