Monocyte Chemotactic Protein 1 (MCP1)
[Edit]CCL2; GDCF2; HC11; HSMCR30; MCAF; MCP1; SCYA2; SMC-CF; Chemokine C-C-Motif Ligand 2; Monocyte Chemotactic And Activating Factor; Monocyte Secretory Protein JE
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CCL2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). This chemokine is produced predominantly by macrophages and endothelial cells and is a potent chemotactic factor for monocytes as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa.
CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. Expression of this proinflammatory chemokine is increased in atherosclerotic lesions, and inhibition of its expression or that of its receptor, CC chemokine receptor 2 (CCR2), reduces the extent of atheroma formation in hypercholesterolemic mice.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Ra01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA087Ra61 | Eukaryotic Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA087Ra01 | Active Monocyte Chemotactic Protein 1 (MCP1) | Cell culture; Activity Assays. | |
| APA087Ra61 | Active Monocyte Chemotactic Protein 1 (MCP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA087Ra01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| PAA087Ra02 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA087Mi | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEA087Ra | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Gu01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA087Gu01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| Assay Kits | SEA087Gu | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Hamster (Chinese hamster)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Ha01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Monocyte Chemotactic Protein 1 (MCP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Si01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA087Si61 | Eukaryotic Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA087Si61 | Active Monocyte Chemotactic Protein 1 (MCP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA087Si01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| LAA087Si71 | Biotin-Linked Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC. | |
| LAA087Si81 | FITC-Linked Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IF. | |
| MAA087Si21 | Monoclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA087Si | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Po01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA087Po02 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA087Po61 | Eukaryotic Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA087Po61 | Active Monocyte Chemotactic Protein 1 (MCP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA087Po01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| MAA087Po21 | Monoclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. | |
| PAA087Po02 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA087Po | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Bo01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA087Bo61 | Eukaryotic Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA087Bo61 | Active Monocyte Chemotactic Protein 1 (MCP1) | Cell culture; Activity Assays. | |
| Antibodies | PAA087Bo01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Monocyte Chemotactic Protein 1 (MCP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | ELISA Kit Customized Service Offer |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA087Eq01 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA087Eq02 | Recombinant Monocyte Chemotactic Protein 1 (MCP1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA087Eq01 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. |
| PAA087Eq02 | Polyclonal Antibody to Monocyte Chemotactic Protein 1 (MCP1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA087Eq | ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)."Biochem. Biophys. Res. Commun. 159:249-255(1989) [PubMed] [Europe PMC] [Abstract]
- "The human homolog of the JE gene encodes a monocyte secretory protein."Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
- "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE."FEBS Lett. 244:487-493(1989) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family."Int. Immunol. 1:388-397(1989) [PubMed] [Europe PMC] [Abstract]
- "Structure of human monocyte chemotactic protein gene and its regulation by TPA."Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
- "Human monocyte chemoattractant protein-1 (MCP-1)."Adv. Exp. Med. Biol. 305:47-56(1991) [PubMed] [Europe PMC] [Abstract]
- "The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo."Mol. Cell. Biochem. 126:61-68(1993) [PubMed] [Europe PMC] [Abstract]
- "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition."Oncogene 19:3235-3244(2000) [PubMed] [Europe PMC] [Abstract]
- "Protein with cytokine activity, recombinant DNA, expression vector and hosts for obtaining it."Patent number EP0488900, 03-JUN-1992
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions."Proc. Natl. Acad. Sci. U.S.A. 86:1850-1854(1989) [PubMed] [Europe PMC] [Abstract]
- "Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form."Biochem. Biophys. Res. Commun. 167:904-909(1990) [PubMed] [Europe PMC] [Abstract]
- "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus."Genomics 10:489-492(1991) [PubMed] [Europe PMC] [Abstract]
- "Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis."J. Biol. Chem. 269:15918-15924(1994) [PubMed] [Europe PMC] [Abstract]
- "Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant."J. Exp. Med. 183:681-685(1996) [PubMed] [Europe PMC] [Abstract]
- "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
- "Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding."J. Biol. Chem. 273:29641-29647(1998) [PubMed] [Europe PMC] [Abstract]
- "Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B."J. Biol. Chem. 273:33157-33165(1998) [PubMed] [Europe PMC] [Abstract]
- "Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2."Biochemistry 38:16167-16177(1999) [PubMed] [Europe PMC] [Abstract]
- "Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2."Biochemistry 38:13013-13025(1999) [PubMed] [Europe PMC] [Abstract]
- "Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo."J. Biol. Chem. 279:22294-22305(2004) [PubMed] [Europe PMC] [Abstract]
- "Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress."J. Lipid Res. 54:734-743(2013) [PubMed] [Europe PMC] [Abstract]
- "Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8."Protein Eng. 4:263-269(1991) [PubMed] [Europe PMC] [Abstract]
- "Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer."Biochemistry 35:6569-6584(1996) [PubMed] [Europe PMC] [Abstract]
- "The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions."Nat. Struct. Biol. 4:64-69(1997) [PubMed] [Europe PMC] [Abstract]
- "A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis."J. Exp. Med. 202:1649-1658(2005) [PubMed] [Europe PMC] [Abstract]