Interleukin 1 Receptor Type I (IL1R1)
[Edit]CD121a; CD121-A; IL1-R1; IL1R; IL1RA; P80; CD121 Antigen-Like Family Member A; Interleukin-1 Receptor Alpha
Interleukin 1 Receptor Type I is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Both human IL1R gene and mouse gene containing a single membrane-spanning segment, a large cytoplasmic region, and an extracellular, IL1-binding portion composed of 3 immunoglobulin-like domains.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA066Mu01 | Recombinant Interleukin 1 Receptor Type I (IL1R1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA066Mu02 | Recombinant Interleukin 1 Receptor Type I (IL1R1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA066Mu01 | Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1) | WB; IHC; ICC; IP. |
PAA066Mu02 | Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA066Mu | ELISA Kit for Interleukin 1 Receptor Type I (IL1R1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
- "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor."Nucleic Acids Res. 17:10114-10114(1989) [PubMed] [Europe PMC] [Abstract]
- "Cloning the interleukin 1 receptor from human T cells."Proc. Natl. Acad. Sci. U.S.A. 86:8946-8950(1989) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I."Cytokine 5:427-435(1993) [PubMed] [Europe PMC] [Abstract]
- "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."J. Immunol. 153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]
- "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."Proc. Natl. Acad. Sci. U.S.A. 94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]
- "Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I."FEBS Lett. 438:49-54(1998) [PubMed] [Europe PMC] [Abstract]
- "Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways."J. Biol. Chem. 275:4670-4678(2000) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta."Nature 386:190-194(1997) [PubMed] [Europe PMC] [Abstract]
- "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist."Nature 386:194-200(1997) [PubMed] [Europe PMC] [Abstract]
- "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1."J. Biol. Chem. 275:36927-36933(2000) [PubMed] [Europe PMC] [Abstract]