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Chemokine (C-X-C Motif) Ligand 1 (CXCL1)

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NAP3; GRO1; GROa; GRO-A; MGSA-A; NAP3; SCYB1; Chemokine C-X-C-Motif Ligand 1; Melanoma Growth Stimulating Activity Alpha; Fibroblast Secretory Protein

Chemokine (C-X-C Motif) Ligand 1 (CXCL1)
CCC A041
HGNC 4602
MGI 3037818
PubMed 23027620
RGD 619869
UniProt P09341
Wiki CXCL1

CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis.CXCL1 is expressed by macrophages, neutrophils and epithelial cells,and has neutrophil chemoattractant activity.CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines.An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA041Hu01 Recombinant Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
APA041Hu01 Active Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Cell culture; Activity Assays.
Antibodies PAA041Hu01 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; ICC; IHC-P; IHC-F; ELISA.
MAA041Hu22 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
LAA041Hu71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC.
PAA041Hu02 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
Assay Kits SEA041Hu ELISA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA041Hu CLIA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA041Mu01 Recombinant Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA041Mu02 Recombinant Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA041Mu03 Recombinant Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA041Mu61 Eukaryotic Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
APA041Mu01 Active Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Cell culture; Activity Assays.
APA041Mu61 Active Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Cell culture; Activity Assays.
APA041Mu02 Active Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Cell culture; Activity Assays.
Antibodies PAA041Mu01 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
LAA041Mu71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC.
LAA041Mu81 FITC-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IF.
PAA041Mu02 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
PAA041Mu03 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
Assay Kits SEA041Mu ELISA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA041Mu CLIA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA041Ra01 Recombinant Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA041Ra11 BSA Conjugated Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Immunogen; SDS-PAGE; WB.
CPA041Ra21 OVA Conjugated Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Immunogen; SDS-PAGE; WB.
Antibodies PAA041Ra01 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
LAA041Ra71 Biotin-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC.
LAA041Ra81 FITC-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IF.
MAA041Ra21 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
PAA041Ra08 Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
LAA041Ra72 Biotin-Linked Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC.
MAA041Ra28 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
MAA041Ra22 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
MAA041Ra23 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
MAA041Ra24 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
MAA041Ra25 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
MAA041Ra27 Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 1 (CXCL1) WB; IHC; ICC; IP.
Assay Kits SEA041Ra ELISA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA041Ra CLIA Kit for Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Chemiluminescent immunoassay for Antigen Detection.
  1. "Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells."Proc. Natl. Acad. Sci. U.S.A. 84:7188-7192(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin."EMBO J. 7:2025-2033(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene."Nucleic Acids Res. 18:6453-6453(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity."J. Exp. Med. 171:1091-1100(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts."Biochem. J. 259:585-588(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale."Adv. Exp. Med. Biol. 305:97-107(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Expression and secretion of gro/MGSA by stimulated human endothelial cells."EMBO J. 8:1761-1766(1989) [PubMed] [Europe PMC] [Abstract]
  11. "1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy."FEBS Lett. 330:302-306(1993) [PubMed] [Europe PMC] [Abstract]
  12. "The solution structure of melanoma growth stimulating activity."J. Mol. Biol. 242:252-270(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy."J. Biol. Chem. 269:32909-32915(1994) [PubMed] [Europe PMC] [Abstract]