FMS Like Tyrosine Kinase 3 Ligand (Flt3L)
[Edit]FLT3LG; FLT3-LG; Flt3-L; FL; Fms-Related Tyrosine Kinase 3 ligand; SL cytokine
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The Flt3l is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.
FLT3L is crucial for steady-state pDC and cDC development . A lack of FLT3L results in low levels of DCs.Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA038Hu01 | Recombinant FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA038Hu01 | Active FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Cell culture; Activity Assays. | |
| Antibodies | PAA038Hu01 | Polyclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB; IHC; ICC; IP. |
| MAA038Hu22 | Monoclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB; IHC; ICC; IP. | |
| MAA038Hu21 | Monoclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB | |
| LAA038Hu94 | HRP-Linked Monoclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB; IHC; ICC. | |
| Assay Kits | SEA038Hu | ELISA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA038Hu | CLIA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA038Mu01 | Recombinant FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA038Mu02 | Recombinant FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA038Mu01 | Polyclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB,IHC |
| PAA038Mu02 | Polyclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA038Mu | ELISA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA038Mu | CLIA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA038Ra01 | Recombinant FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | ELISA Kit Customized Service Offer |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | APA038Si01 | Active FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Cell culture; Activity Assays. |
| Antibodies | n/a | Monoclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for FMS Like Tyrosine Kinase 3 Ligand (Flt3L) | ELISA Kit Customized Service Offer |
- "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs." Nature 368:643-648(1994) [PubMed] [Europe PMC] [Abstract]
- "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells."Blood 83:2795-2801(1994) [PubMed] [Europe PMC] [Abstract]
- "Structural analysis of human and murine flt3 ligand genomic loci."Oncogene 11:1165-1172(1995) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots."Nat. Struct. Biol. 7:486-491(2000) [PubMed] [Europe PMC] [Abstract]