ELISA Kit for Interleukin 10 (IL10)

CSIF; IL10A; TGIF; Cytokine Synthesis Inhibitory Factor

Specificity

This assay has high sensitivity and excellent specificity for detection of Interleukin 10 (IL10).
No significant cross-reactivity or interference between Interleukin 10 (IL10) and analogues was observed.

Recovery

Matrices listed below were spiked with certain level of recombinant Interleukin 10 (IL10) and the recovery rates were calculated by comparing the measured value to the expected amount of Interleukin 10 (IL10) in samples.

Matrix Recovery range (%) Average(%)
serum(n=5) 90-97 94
EDTA plasma(n=5) 79-90 84
heparin plasma(n=5) 81-96 90

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 10 (IL10) were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 10 (IL10) were tested on 3 different plates, 8 replicates in each plate.
CV(%) = SD/meanX100
Intra-Assay: CV<10%
Inter-Assay: CV<12%

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Interleukin 10 (IL10) and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample 1:2 1:4 1:8 1:16
serum(n=5) 78-97% 96-105% 88-96% 80-102%
EDTA plasma(n=5) 92-102% 80-98% 87-101% 83-95%
heparin plasma(n=5) 90-102% 84-101% 98-105% 81-90%

Stability

The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Reagents and materials provided

Reagents Quantity Reagents Quantity
Pre-coated, ready to use 96-well strip plate 1 Plate sealer for 96 wells 4
Standard 2 Standard Diluent 1×20mL
Detection Reagent A 1×120µL Assay Diluent A 1×12mL
Detection Reagent B 1×120µL Assay Diluent B 1×12mL
TMB Substrate 1×9mL Stop Solution 1×6mL
Wash Buffer (30 × concentrate) 1×20mL Instruction manual 1

Assay procedure summary

1. Prepare all reagents, samples and standards;
2. Add 100µL standard or sample to each well. Incubate 1 hours at 37°C;
3. Aspirate and add 100µL prepared Detection Reagent A. Incubate 1 hour at 37°C;
4. Aspirate and wash 3 times;
5. Add 100µL prepared Detection Reagent B. Incubate 30 minutes at 37°C;
6. Aspirate and wash 5 times;
7. Add 90µL Substrate Solution. Incubate 10-20 minutes at 37°C;
8. Add 50µL Stop Solution. Read at 450nm immediately.

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Int J Neurosci Downregulation of ROCK2 attenuates alcohol-induced inflammation and oxidative stress in astrocytes Pubmed: 32942936
THERIOGENOLOGY Porcine soluble CD83 alleviates LPS-induced abortion in mice by promoting Th2 cytokine production, Treg cell generation and trophoblast invasion Pubmed: 32810792
Theriogenology A comparative study on various immunological parameters influencing embryo survivability in crossbred dairy cows Pubmed: 32810791
JOURNAL OF MOLECULAR NEUROSCIENCE Different Activation of IL-10 in the Hippocampus and Prefrontal Cortex During Neurodegeneration Caused by Trimethyltin Chloride Pubmed: 32803646
BRAIN BEHAVIOR AND IMMUNITY Active smoking, sleep quality and cerebrospinal fluid biomarkers of neuroinflammation Pubmed: 32717405
Bioengineered Down-regulation of ROCK2 alleviates ethanol-induced cerebral nerve injury partly by the suppression of the NF-κB signaling pathway Pubmed: 32684089
EXPERIMENTAL DERMATOLOGY Decreased suppression of CD8+ and CD4+ T cells by peripheral Regulatory T cells in Generalized Vitiligo due to reduced NFATC1 and FOXP3 proteins Pubmed: 32682346
Parasites & Vectors Fasciola gigantica excretory-secretory products (FgESPs) modulate the differentiation and immune functions of buffalo dendritic cells through a mechanism … Pubmed: 32680553
Life Sci Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study Pubmed: 32652140
Front Pharmacol Cyclic Peptide Extracts Derived From Pseudostellaria heterophylla Ameliorates COPD via Regulation of the TLR4/MyD88 Pathway Proteins Pubmed: 32581806
BIOTECHNOLOGY LETTERS Recombinant ferritin nanoparticles can induce dendritic cell maturation through TLR4/NF-κB pathway Pubmed: 32567013
INTERNATIONAL IMMUNOPHARMACOLOGY A potential drug combination of omeprazole and patchouli alcohol significantly normalizes oxidative stress and inflammatory responses against gastric ulcer in ethanol … Pubmed: 32559721
Int J Mol Sci Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome Pubmed: 32403267
BRAIN BEHAVIOR AND IMMUNITY USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in … Pubmed: 32335193
JAMA Surgery Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment Pubmed: 28593326
BIOMEDICINE & PHARMACOTHERAPY Protective effects of bee bread on testicular oxidative stress, NF-κB-mediated inflammation, apoptosis and lactate transport decline in obese male rats Pubmed: 33152939
Frontiers in Pharmacology M10, a Myricetin-3-ObD-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice Pubmed: 33041798
κ‑opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF‑κB/HIF‑1α pathway Pubmed: 32509012
Molecular Medicine Reports Placenta‑derived mesenchymal stem cells ameliorate lipopolysaccharide‑induced inflammation in RAW264. 7 cells and acute lung injury in rats Pubmed: 32626979
Food & Function Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial …
Nanoscale Research Letters Protective Effects of Carbon Dots Derived from Phellodendri Chinensis Cortex Carbonisata against Deinagkistrodon acutus Venom-Induced Acute Kidney …
Journal of Biochemical and Molecular Toxicology Vitamin D3 and calcium cosupplementation alleviates cadmium hepatotoxicity in the rat: Enhanced antioxidative and anti‐inflammatory actions by remodeling cellular …
Journal of Functional Foods Wine pomace product modulates oxidative stress and microbiota in obesity high-fat diet-fed rats
Evaluation of lipopolysaccharide-induced acute lung injury attenuation in mice by Glycyrrhiza glabra
Applied materials today Tanshinone IIA-loaded aligned microfibers facilitate stem cell recruitment and capillary formation by inducing M2 macrophage polarization
letter in applied nanobioscience Phytochemical and Toxicological Effect of Ethanol Extract of Heliotropium Indicum on Liver of Male Albino Rats
biosciences biotechnology research asia Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet.
Phytomedicine Menthacarin attenuates experimental colitis
ACS Biomaterials Science & Engineering Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction
Immunomodulatory effects of sCD83 via induction of TGF-β1 and IDO: an in vitro and rat orthotopic liver transplantation study
Effects of minocycline on neuroinflammation, gut microbiome and hippocampal neurogenesis in rats with Gulf War Illness
Minocycline Alleviate A Rat Model Of Gulf War Illness Via Altering Gut Microbiome, Attenuating Neuroinflammation And Enhancing Hippocampal Neurogenesis
Experimental autoimmune encephalomyelitis inhibited by Huangqi Guizhi Wuwu Decoction by enhancing Th2 cytokine
EC NEUROLOGY Malted Barley Ameliorated Spinal Cord Injuries of Offspring of Hypercholesterolemic Mother Rats
Catalog No. Related products for research use of Canis familiaris; Canine (Dog) Organism species Applications (RESEARCH USE ONLY!)
RPA056Ca01 Recombinant Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
APA056Ca61 Active Interleukin 10 (IL10) Cell culture; Activity Assays.
EPA056Ca61 Eukaryotic Interleukin 10 (IL10) Positive Control; Immunogen; SDS-PAGE; WB.
PAA056Ca01 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
PAA056Ca06 Polyclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MAA056Ca21 Monoclonal Antibody to Interleukin 10 (IL10) WB; IHC; ICC; IP.
MEA056Ca Mini Samples ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA056Ca ELISA Kit for Interleukin 10 (IL10) Enzyme-linked immunosorbent assay for Antigen Detection.
KSA056Ca01 ELISA Kit DIY Materials for Interleukin 10 (IL10) Main materials for "Do It(ELISA Kit) Yourself"