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Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

FH3; HCHOLA3; NARC1; Hypercholesterolemia,Autosomal Dominant 3; Neural apoptosis-regulated convertase 1; Proprotein convertase 9; Subtilisin/kexin-like protease PC9

  • Product No.RPE189Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted, Lysosome, Cytoplasm, Golgi apparatus, Endoplasmic reticulum lumen, Endosome
  • Predicted Molecular Mass58.1kDa
  • Accurate Molecular Mass58kDa(Analysis of differences refer to the manual)
  • Residues & TagsTrp164~Phe428 with N-terminal His and GST Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 90%
  • Isoelectric Point5.9
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 199  US$ 498  US$ 996  US$ 2988  US$ 7470 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Biological Trace Element Research Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers pubmed:28409410
BASIC RESEARCH IN CARDIOLOGY Autocrine effects of PCSK9 on cardiomyocytes Pubmed: 33169229
J Transl Med Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans 33407555
Metabolism MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice 33775647
Eur Rev Med Pharmacol Sci Association of serum proprotein convertase Subtilisin/Kexin Type 9 (PCSK9) level with thyroid function disorders 34533801
Clin Exp Hypertens Proprotein convertase subtilisin/kexin type 9 is associated with atherosclerosis in patients with Behcet's disease Pubmed:35502687
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPE189Ra01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
PAE189Ra01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
MAE189Ra23 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
MAE189Ra22 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
MAE189Ra21 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC
SEE189Ra ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Enzyme-linked immunosorbent assay for Antigen Detection.
LME189Ra Multiplex Assay Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.