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Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

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FH3; HCHOLA3; NARC1; Hypercholesterolemia,Autosomal Dominant 3; Neural apoptosis-regulated convertase 1; Proprotein convertase 9; Subtilisin/kexin-like protease PC9

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)
CCC E189
HGNC 20001
MGI 2140260
PubMed 18666258
RGD 728909
UniProt Q8NBP7
Wiki PCSK9
PCSK9 belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins, which could lead to hypercholesterolemia. Inhibition of PSCK9 function is currently being explored as a means of lowering cholesterol levels. PCSK9 may also have a role in the differentiation of cortical neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE189Hu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
RPE189Hu02 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE189Hu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
PAE189Hu02 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
LAE189Hu71 Biotin-Linked Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC.
Assay Kits SEE189Hu ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE189Mu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
RPE189Mu02 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE189Mu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
PAE189Mu02 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
Assay Kits SEE189Mu ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE189Ra01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE189Ra21 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC
PAE189Ra01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
MAE189Ra23 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
MAE189Ra22 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) WB; IHC; ICC; IP.
Assay Kits SEE189Ra ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Polyclonal Antibody Customized Service Offer
Assay Kits SEE189Rb ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleic acid molecules derived from rat brain and programmed cell death models."Patent number WO0131007, 03-MAY-2001
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  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Functional characterization of Narc 1, a novel proteinase related to proteinase K."Arch. Biochem. Biophys. 420:55-67(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications."J. Biol. Chem. 281:30561-30572(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR."Traffic 8:718-732(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Self-association of human PCSK9 correlates with its LDLR-degrading activity."Biochemistry 47:1631-1639(2008) [PubMed] [Europe PMC] [Abstract]
  11. "PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1."EMBO Rep. 9:916-922(2008) [PubMed] [Europe PMC] [Abstract]
  12. "PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans."FEBS J. 275:3480-3493(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."J. Biol. Chem. 283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation."Biochem. Biophys. Res. Commun. 415:515-518(2011) [PubMed] [Europe PMC] [Abstract]
  17. "A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor."J. Biol. Chem. 286:5464-5470(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein."J. Biol. Chem. 286:43054-43061(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]
  21. "PCSK9: an enigmatic protease."Biochim. Biophys. Acta 1781:184-191(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular basis of PCSK9 function."Atherosclerosis 203:1-7(2009) [PubMed] [Europe PMC] [Abstract]
  23. "The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis."J. Intern. Med. 266:507-519(2009) [PubMed] [Europe PMC] [Abstract]
  24. "PCSK9: a convertase that coordinates LDL catabolism."J. Lipid Res. 50:S172-S177(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Proprotein convertase subtilisin/kexin type 9 (PCSK9): from structure-function relation to therapeutic inhibition."Nutr. Metab. Cardiovasc. Dis. 21:835-843(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease."Hum. Mutat. 30:520-529(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients."Atherosclerosis 222:158-166(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)."J. Biol. Chem. 287:19266-19274(2012) [PubMed] [Europe PMC] [Abstract]
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  31. "A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol."Am. J. Hum. Genet. 78:410-422(2006) [PubMed] [Europe PMC] [Abstract]
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  33. "Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels."Hum. Mutat. 33:448-455(2012) [PubMed] [Europe PMC] [Abstract]