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Mdm2 p53 Binding Protein Homolog (MDM2)

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HDMX; hdm2; Mouse Double Minute 2,Human Homolog Of p53-Binding Protein; Oncoprotein Mdm2

Mdm2 p53 Binding Protein Homolog (MDM2)
CCC G790
HGNC 6973
MGI 96952
PubMed 15953616
RGD 1305332
UniProt Q00987
Wiki Mdm2
Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation.The key target of Mdm2 is the p53 tumor suppressor. Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity.
Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. Mdm2 is a p53 responsive gene—that is, its transcription can be activated by p53. Thus when p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher Mdm2 protein levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG790Hu01 Recombinant Mdm2 p53 Binding Protein Homolog (MDM2) Positive Control; Immunogen; SDS-PAGE; WB.
APG790Hu01 Active Mdm2 p53 Binding Protein Homolog (MDM2) Cell culture; Activity Assays.
RPG790Hu02 Recombinant Mdm2 p53 Binding Protein Homolog (MDM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG790Hu21 Monoclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) WB; IHC; ICC; IP.
PAG790Hu01 Polyclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) WB; IHC; ICC; IP.
Assay Kits SEG790Hu ELISA Kit for Mdm2 p53 Binding Protein Homolog (MDM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG790Mu01 Recombinant Mdm2 p53 Binding Protein Homolog (MDM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG790Mu02 Recombinant Mdm2 p53 Binding Protein Homolog (MDM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG790Mu01 Polyclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) WB; IHC; ICC; IP.
PAG790Mu02 Polyclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) WB; IHC; ICC; IP.
Assay Kits SEG790Mu ELISA Kit for Mdm2 p53 Binding Protein Homolog (MDM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mdm2 p53 Binding Protein Homolog (MDM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mdm2 p53 Binding Protein Homolog (MDM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mdm2 p53 Binding Protein Homolog (MDM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mdm2 p53 Binding Protein Homolog (MDM2) ELISA Kit Customized Service Offer
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