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Protein Kinase B Alpha (PKBa)

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AKT1; AKT; PKB-A; Proto-oncogene c-Akt; RAC-Alpha Serine/Threonine-Protein Kinase; V-akt Murine Thymoma Viral Oncogene Homolog 1

Protein Kinase B Alpha (PKBa)
CCC C231
HGNC 391
MGI 87986
PubMed 15047604
RGD 2081
UniProt P31749
Wiki PKB
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase.
In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC231Hu01 Recombinant Protein Kinase B Alpha (PKBa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC231Hu01 Polyclonal Antibody to Protein Kinase B Alpha (PKBa) WB; IHC; ICC; IP.
MAC231Hu21 Monoclonal Antibody to Protein Kinase B Alpha (PKBa) WB; IHC; ICC; IP.
Assay Kits SEC231Hu ELISA Kit for Protein Kinase B Alpha (PKBa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC231Mu01 Recombinant Protein Kinase B Alpha (PKBa) Positive Control; Immunogen; SDS-PAGE; WB.
RPC231Mu02 Recombinant Protein Kinase B Alpha (PKBa) Positive Control; Immunogen; SDS-PAGE; WB.
MPC231Mu01 Phosphorylated Protein Kinase B Alpha (PKBa) n/a
Antibodies PAC231Mu01 Polyclonal Antibody to Protein Kinase B Alpha (PKBa) WB; IHC; ICC; IP.
PAC231Mu02 Polyclonal Antibody to Protein Kinase B Alpha (PKBa) WB; IHC; ICC; IP.
AAC231Mu01 Anti-Phosphorylated Protein Kinase B Alpha (PKBa) Polyclonal Antibody WB.
AAC231Mu02 Anti-Phosphorylated Protein Kinase B Alpha (PKBa) Monoclonal Antibody WB.
Assay Kits SEC231Mu ELISA Kit for Protein Kinase B Alpha (PKBa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase B Alpha (PKBa) Recombinant Protein Customized Service Offer
Antibodies PAC231Ra01 Polyclonal Antibody to Protein Kinase B Alpha (PKBa) WB; IHC; ICC; IP.
Assay Kits SEC231Ra ELISA Kit for Protein Kinase B Alpha (PKBa) Enzyme-linked immunosorbent assay for Antigen Detection.
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