Dopamine Receptor D1 (DRD1)

Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport.

DRD1 gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB299Hu01 Recombinant Dopamine Receptor D1 (DRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB299Hu01 Polyclonal Antibody to Dopamine Receptor D1 (DRD1) WB; IHC; ICC; IP.
MAB299Hu22 Monoclonal Antibody to Dopamine Receptor D1 (DRD1) WB; IHC; ICC; IP.
Assay Kits SEB299Hu ELISA Kit for Dopamine Receptor D1 (DRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopamine Receptor D1 (DRD1) Recombinant Protein Customized Service Offer
Antibodies PAB299Mu01 Polyclonal Antibody to Dopamine Receptor D1 (DRD1) WB; IHC; ICC; IP.
Assay Kits SEB299Mu ELISA Kit for Dopamine Receptor D1 (DRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB299Ra01 Recombinant Dopamine Receptor D1 (DRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB299Ra01 Polyclonal Antibody to Dopamine Receptor D1 (DRD1) WB; IHC; ICC; IP.
MAB299Ra21 Monoclonal Antibody to Dopamine Receptor D1 (DRD1) WB; IHC; ICC; IP.
Assay Kits SEB299Ra ELISA Kit for Dopamine Receptor D1 (DRD1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and expression of the gene for a human D1 dopamine receptor."Nature 347:72-76(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of human and rat D1 dopamine receptors."Nature 347:76-80(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Human dopamine D1 receptor encoded by an intronless gene on chromosome 5."Nature 347:80-83(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms."Neuropsychopharmacology 8:131-135(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor."Eur. J. Pharmacol. 386:305-312(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]