Inhibin Beta A (INHbA)

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INH-BA; INHB-A; EDF; FRP; Activin A,Activin AB Alpha Polypeptide; Activin beta-A chain; Erythroid differentiation protein

Inhibin Beta A (INHbA)

INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. Serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion. The beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA838Hu01 Recombinant Inhibin Beta A (INHbA) Positive Control; Immunogen; SDS-PAGE; WB.
EPA838Hu61 Eukaryotic Inhibin Beta A (INHbA) Positive Control; Immunogen; SDS-PAGE; WB.
APA838Hu61 Active Inhibin Beta A (INHbA) Cell culture; Activity Assays.
CPA838Hu21 OVA Conjugated Inhibin Beta A (INHbA) Immunogen; SDS-PAGE; WB.
Antibodies PAA838Hu01 Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
MAA838Hu22 Monoclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
PAA838Hu06 Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
MAA838Hu28 Monoclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
Assay Kits CEA838Hu ELISA Kit for Inhibin Beta A (INHbA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inhibin Beta A (INHbA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inhibin Beta A (INHbA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inhibin Beta A (INHbA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inhibin Beta A (INHbA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inhibin Beta A (INHbA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA838Ra01 Recombinant Inhibin Beta A (INHbA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA838Ra01 Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
MAA838Ra22 Monoclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
LAA838Ra71 Biotin-Linked Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC.
LAA838Ra81 FITC-Linked Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IF.
Assay Kits SEA838Ra ELISA Kit for Inhibin Beta A (INHbA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA838Bo01 Recombinant Inhibin Beta A (INHbA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA838Bo01 Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IP.
LAA838Bo71 Biotin-Linked Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC.
LAA838Bo81 FITC-Linked Polyclonal Antibody to Inhibin Beta A (INHbA) WB; IHC; ICC; IF.
Assay Kits SEA838Bo ELISA Kit for Inhibin Beta A (INHbA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure of two human ovarian inhibins."Biochem. Biophys. Res. Commun. 135:957-964(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain."Proc. Natl. Acad. Sci. U.S.A. 85:2434-2438(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and sequence analysis of the human activin beta A subunit gene."DNA Seq. 2:103-110(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human inhibin genes. Genomic characterisation and sequencing."FEBS Lett. 206:329-334(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)."Endocrinology 144:1671-1674(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions."EMBO J. 22:1555-1566(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity."J. Biol. Chem. 283:32831-32838(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Germline mutations of inhibins in early-onset ovarian epithelial tumors." Hum. Mutat. 35:294-297(2014) [PubMed] [Europe PMC] [Abstract]