Galectin 1 (GAL1)

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LGALS1; GBP; HLBP14; Galaptin; Lectin,Galactoside-Binding Soluble 1; 14 kDa laminin-binding protein; Lactose-binding lectin 1; Putative MAPK-activating protein PM12; S-Lac lectin

Galectin 1 (GAL1)
Galectin-1 is one of the most important lectins to date participating in the malignant tumor development. With more and more data available on its expression in tumors it is already clear that this lectin is an important target for cancer diagnostics and treatment.Its first involvement in cancer was associated with cell adhesion. Later on the lectin was shown to induce apoptosis of activated T-cells, and experiments have confirmed that cancer cells express galectin-1 also to protect themselves from immune response. Latest finding is a participation of galectin-1 in tumor angiogenesis as an angiogenic factor. In most of the cases described, galectin-1 is up-regulated in tumors in comparison to normal tissue. Moreover, the presence of the lectin is associated with metastases and poor prognosis of disease outcome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Hu01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Hu01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
MAA321Hu22 Monoclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
LAA321Hu71 Biotin-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC.
LAA321Hu81 FITC-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IF.
Assay Kits SEA321Hu ELISA Kit for Galectin 1 (GAL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA321Hu CLIA Kit for Galectin 1 (GAL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Mu02 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA321Mu01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAA321Mu71 Biotin-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC.
LAA321Mu81 FITC-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IF.
PAA321Mu02 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
Assay Kits SEA321Mu ELISA Kit for Galectin 1 (GAL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Ra01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA321Ra02 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Ra01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
PAA321Ra02 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
MAA321Ra22 Monoclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
LAA321Ra71 Biotin-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC.
LAA321Ra81 FITC-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IF.
Assay Kits SEA321Ra ELISA Kit for Galectin 1 (GAL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Po01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Po01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
Assay Kits SEA321Po ELISA Kit for Galectin 1 (GAL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Bo01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Bo01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
LAA321Bo71 Biotin-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC.
LAA321Bo81 FITC-Linked Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IF.
MAA321Bo21 Monoclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
Assay Kits SEA321Bo ELISA Kit for Galectin 1 (GAL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Cp01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Cp01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Galectin 1 (GAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Galectin 1 (GAL1) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA321Ov01 Recombinant Galectin 1 (GAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA321Ov01 Polyclonal Antibody to Galectin 1 (GAL1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Galectin 1 (GAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Galectin 1 (GAL1) ELISA Kit Customized Service Offer
  1. "Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin."Biochim. Biophys. Acta 1008:85-91(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, characterization, and expression of a human 14-kDa lectin."J. Biol. Chem. 264:1310-1316(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene."Biochem. J. 259:291-294(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance."Proc. Natl. Acad. Sci. U.S.A. 105:15819-15824(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic sequence and organization of two members of a human lectin gene family."Biochemistry 30:82-89(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta."J. Biochem. 104:1-4(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Beta-galactosidase soluble lectin from human brain: complete amino acid sequence."Neurochem. Int. 18:275-281(1991)
  13. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  14. , Submitted (DEC-2008) to UniProtKB
  15. "Further characterization and structural studies on human placenta lectin."J. Biochem. 101:987-995(1987) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin."Arch. Biochem. Biophys. 297:132-138(1992) [PubMed] [Europe PMC] [Abstract]
  17. "Human splenic galaptin: physicochemical characterization."Biochemistry 29:5309-5314(1990) [PubMed] [Europe PMC] [Abstract]
  18. "Apoptosis of T cells mediated by galectin-1."Nature 378:736-739(1995) [PubMed] [Europe PMC] [Abstract]
  19. "Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45."Immunol. Lett. 67:193-202(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells."Glycobiology 10:413-419(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation."Int. J. Cancer 91:167-172(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Presentation of galectin-1 by extracellular matrix triggers T cell death."J. Biol. Chem. 279:4705-4712(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Abnormal proteins in primary breast cancer tissues from 25 Sudanese patients."Eur. J. Inflamm. 6:115-121(2008)
  24. "A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death." Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  29. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  30. "Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis."Mol. Cancer Res. 11:74-85(2013) [PubMed] [Europe PMC] [Abstract]
  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding."J. Mol. Biol. 343:957-970(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1."Glycobiology 18:1065-1073(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose."Biochemistry 48:786-791(2009) [PubMed] [Europe PMC] [Abstract]