Platelet Factor 4 (PF4)

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CXCL4; SCYB4; Chemokine C-X-C-Motif Ligand 4; Oncostatin-A; Iroplact

Platelet Factor 4 (PF4)

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family. This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. PF4 autoantibodies have also been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Hu01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
APA172Hu01 Active Platelet Factor 4 (PF4) Cell culture; Activity Assays.
Antibodies PAA172Hu01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
MAA172Hu22 Monoclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
LAA172Hu71 Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC.
LAA172Hu81 FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IF.
Assay Kits SEA172Hu ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA172Hu CLIA Kit for Platelet Factor 4 (PF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Mu01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA172Mu02 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
APA172Mu01 Active Platelet Factor 4 (PF4) Cell culture; Activity Assays.
Antibodies PAA172Mu01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
PAA172Mu02 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
LAA172Mu71 Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC.
LAA172Mu81 FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IF.
Assay Kits SEA172Mu ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA172Mu CLIA Kit for Platelet Factor 4 (PF4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Ra01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA172Ra02 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA172Ra01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
LAA172Ra71 Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC.
LAA172Ra81 FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IF.
PAA172Ra02 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
MAA172Ra21 Monoclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
Assay Kits SEA172Ra ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Rb01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA172Rb51 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
MAA172Rb21 Monoclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
Assay Kits SEA172Rb ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Po01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA172Po01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
MAA172Po21 Monoclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
Assay Kits SEA172Po ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Bo01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA172Bo01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
MAA172Bo21 Monoclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
Assay Kits SEA172Bo ELISA Kit for Platelet Factor 4 (PF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Cp01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA172Cp01 Polyclonal Antibody to Platelet Factor 4 (PF4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Platelet Factor 4 (PF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Factor 4 (PF4) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA172Eq01 Recombinant Platelet Factor 4 (PF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Platelet Factor 4 (PF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet Factor 4 (PF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Platelet Factor 4 (PF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Factor 4 (PF4) ELISA Kit Customized Service Offer
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  2. "Structural and functional comparison of the genes for human platelet factor 4 and PF4alt."Blood 76:336-344(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
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  6. "Isolation, crystallization, and primary amino acid sequence of human platelet factor 4."J. Biol. Chem. 252:6276-6279(1977) [PubMed] [Europe PMC] [Abstract]
  7. "Amino acid sequence of human platelet factor 4."Proc. Natl. Acad. Sci. U.S.A. 74:2256-2258(1977) [PubMed] [Europe PMC] [Abstract]
  8. "Primary structure of human platelet factor 4."Thromb. Res. 11:893-898(1977) [PubMed] [Europe PMC] [Abstract]
  9. "Complete covalent structure of human platelet factor 4."Thromb. Haemost. 42:1652-1660(1980) [PubMed] [Europe PMC] [Abstract]
  10. "A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4."Proc. Natl. Acad. Sci. U.S.A. 92:7799-7803(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1."J. Biol. Chem. 288:13522-13533(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of recombinant human platelet factor 4."Biochemistry 33:8361-8366(1994) [PubMed] [Europe PMC] [Abstract]
  13. "NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer."Biochemistry 34:11399-11409(1995) [PubMed] [Europe PMC] [Abstract]