Nerve Growth Factor (NGF)

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NGFB; Beta-NGF; HSAN5; NGF-B; Beta-Nerve Growth Factor

Nerve Growth Factor (NGF)

Nerve growth factor (NGF) is a naturally occurring molecule in the body which stimulates the growth and differentiation of the sympathetic and certain sensory nerves. NGF is a protein that consists of 3 types of polypeptide chains -- alpha, beta and gamma -- that interact to form the protein. The NGF beta chain (NGFB) is solely responsible for the nerve growth stimulating activity of NGF. The NGFB gene is in chromosome band 1p22. An ointment containing NGF has been reported to help heal bedsores (decubiti).This complex contains 2 identical 118-amino acid beta-chains, which are solely responsible for nerve growth stimulating activity of NGF. Human DNA fragments coding for NGF were identified by Zabel et al. (1984) using a mouse submaxillary cDNA probe.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Hu01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
EPA105Hu61 Eukaryotic Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
APA105Hu01 Active Nerve Growth Factor (NGF) Cell culture; Activity Assays.
Antibodies PAA105Hu01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Hu22 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
LAA105Hu71 Biotin-Linked Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC.
PAA105Hu06 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Hu ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA105Hu CLIA Kit for Nerve Growth Factor (NGF) Chemiluminescent immunoassay for Antigen Detection.
HEA105Hu High Sensitive ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Mu01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA105Mu02 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Mu01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
PAA105Mu02 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Mu ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Ra01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Ra01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Ra21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Ra ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA105Ra CLIA Kit for Nerve Growth Factor (NGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Gu01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Gu01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Gu21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Gu ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Si01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Si01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Si21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Si ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Po01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Po01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Po21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Po ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Bo01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Bo01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Bo21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Bo ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nerve Growth Factor (NGF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nerve Growth Factor (NGF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nerve Growth Factor (NGF) Polyclonal Antibody Customized Service Offer
Assay Kits SEA105Ov ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA105Ga01 Recombinant Nerve Growth Factor (NGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA105Ga01 Polyclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
MAA105Ga21 Monoclonal Antibody to Nerve Growth Factor (NGF) WB; IHC; ICC; IP.
Assay Kits SEA105Ga ELISA Kit for Nerve Growth Factor (NGF) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human beta-nerve growth factor gene sequence highly homologous to that of mouse."Nature 303:821-825(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence homology of human and mouse beta-NGF subunit genes."Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequence of human beta-NGF."Nucleic Acids Res. 18:4020-4020(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequencing of the gene for premature beta nerve growth factor."Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
  9. "The trk proto-oncogene encodes a receptor for nerve growth factor."Cell 65:189-197(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI."J. Biol. Chem. 285:11793-11799(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."Nature 401:184-188(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  13. ErratumNat. Genet. 23:373-373(1999)
  14. "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception."Hum. Mol. Genet. 13:799-805(2004) [PubMed] [Europe PMC] [Abstract]
  15. "A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy."J. Med. Genet. 48:131-135(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort." J. Neurol. 259:1673-1685(2012) [PubMed] [Europe PMC] [Abstract]