Leptin (LEP)

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OB; OBS; Obesity Homolog; Obesity Factor; Obese Protein

Leptin (LEP)

Leptin is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is a 16-kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. Leptin acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family, which is found in many tissues in several alternatively spliced forms. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Hu01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
APA084Hu01 Active Leptin (LEP) Cell culture; Activity Assays.
Antibodies LAA084Hu71 Biotin-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC.
LAA084Hu81 FITC-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IF.
PAA084Hu01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Hu ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA084Hu CLIA Kit for Leptin (LEP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Mu01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA084Mu02 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Mu01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
LAA084Mu71 Biotin-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC.
LAA084Mu81 FITC-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IF.
PAA084Mu02 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Mu21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Mu ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA084Mu CLIA Kit for Leptin (LEP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Ra01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Ra01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
LAA084Ra71 Biotin-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC.
MAA084Ra21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Ra ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA084Ra CLIA Kit for Leptin (LEP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Rb01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Rb51 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Rb21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Rb ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Ca01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Ca01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Ca21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Ca ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Po01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Po01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Po21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Po ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA084Po CLIA Kit for Leptin (LEP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Bo01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Bo01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Bo21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
LAA084Bo71 Biotin-Linked Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC.
Assay Kits SEA084Bo ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Cp01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Cp01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leptin (LEP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leptin (LEP) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leptin (LEP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leptin (LEP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leptin (LEP) Polyclonal Antibody Customized Service Offer
Assay Kits SEA084Ov ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Eq01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Eq01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Eq21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Eq ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA084Ga01 Recombinant Leptin (LEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA084Ga01 Polyclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
MAA084Ga21 Monoclonal Antibody to Leptin (LEP) WB; IHC; ICC; IP.
Assay Kits SEA084Ga ELISA Kit for Leptin (LEP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Positional cloning of the mouse obese gene and its human homologue."Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNature 374:479-479(1995)
  3. "Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue."Diabetes 44:855-858(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure and promoter analysis of the human obese gene."J. Biol. Chem. 271:3971-3974(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Structural organization and chromosomal assignment of the human obese gene."J. Biol. Chem. 270:27728-27733(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity."Diabetes 45:675-678(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily."J. Biol. Chem. 274:22729-22738(1999) [PubMed] [Europe PMC] [Abstract]
  9. ErratumJ. Biol. Chem. 274:28058-28058(1999)
  10. "Leptin is a four-helix bundle: secondary structure by NMR."FEBS Lett. 407:239-242(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the obese protein leptin-E100."Nature 387:206-209(1997) [PubMed] [Europe PMC] [Abstract]
  12. "A novel polymorphism in the leptin gene."Hum. Mutat. 12:220-220(1998)
  13. "A leptin missense mutation associated with hypogonadism and morbid obesity."Nat. Genet. 18:213-215(1998) [PubMed] [Europe PMC] [Abstract]