Top-Ranked ELISA Kits (Cortsterone Cort). Vol.11

Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. As the most important glucocorticoid in mammals, it also has a direct impact on the elongation, differentiation and physiological functions of hippocampal neurons. Corticosterone affects neuronal function by interacting with two types of intracellular receptors, Glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), and membrane receptor-binding proteins that have not yet been fully elucidated. In the condition of stress and aging, the damage to hippocampal morphological and functional would be led by corticosterone rising in plasma, including atrophy of apical dendrites in CA3 vertebral neurons, Inhibition of hippocampal neurons Long-Term Potentiation(LTP), and damage to learning and memory function, etc.