Cloud-Clone MSR1 kit plays a key role in the study of rheumatoid arthritis diagnostic markers

On April 20,2020,professor Zhanguo Li and profressor Xiang-Yang Wang from department of Human & Molecular Genetics, Virginia Commonwealth University co-authored with professor Liang Liu from Macau University of Science and Technology, published a paper titled Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study on Nature commnications. 

The ELISA kit (MSR1, SEB591Hu) of Cloud-Clone brand was chosed to determine the concentation of MSR1 in this article, we are so proud for supporting the reaserchers.

The paper reports a large-scale multicenter study involving training and validation cohorts of 3,262 participants. It shows that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.