A novel neuroinflammation-responsive hydrogel retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease
On October 23, 2021, Weiming Tian, Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, and his team published an article titled "A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease" in Chemical Engineering Journal, which provided a potential early intervention strategy for retarding later AD progression.
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Neuroinflammation is one of the major processes that trigger neuropathological amyloid-β (Aβ) deposition and contribute to Alzheimer’s disease (AD) progression. Naked mole rats, which are the longest living rodents and exhibit negligible senescence, have a special brain microenvironment characterized by high-molecular-mass hyaluronan (HMM-HA) and high levels of neuregulin 1 (NRG1), which are related to resistance to neuro-inflammation and Aβ deposition, leading to protection from AD. Thus, mimicking the unique brain microenvironment of the naked mole rat as a strategy for AD treatment is of critical interest. Here, naked mole rat HMM-HA and NRG1 were used to establish an injectable neuroinflammation-responsive triglycerol monostearate (TM)-HA-NRG1 hydrogel to alter the brain microenvironment in the early to late stages of AD. Intracerebroventricular (ICV) delivery of the hydrogel resulted in significant mitigation of Aβ plaque formation and complement C1q deposition in the hippocampus. Interestingly, we found that C1q deposition on pericytes was probably associated with capillary dysfunction. Furthermore, continuous intervention obviously reduced C1q deposition on pericytes and improved the oxygen supply to the brain. Importantly, in 16-month-old AD mice, cognitive decline was significantly ameliorated after TM-HA-NRG1 hydrogel treatment. Thus, the work reported here provides a potential early intervention strategy for retarding later AD progression.
The nervous system is a system that plays a dominant role in the regulation of physiological functions in the body. It is mainly composed of nerve tissue and is divided into two parts: the central nervous system and the peripheral nervous system. The central nervous system in turn includes the brain and spinal cord, and the peripheral nervous system includes the cranial nerves and spinal nerves. In biological individuals, exercise the role of "command" and control the coordination of various tissues and organs of the body. Neurological diseases may be caused by external factors or personal genetic factors, including cerebrovascular diseases, periodic paralysis, progressive muscular dystrophy, myotonic dystrophy, and ataxia. Nervous system diseases are difficult to cure at the current medical level, mainly relying on early prevention and treatment. Therefore, early diagnosis and early intervention are of great significance for improving the long-term prognosis of neurological diseases.With the rapid development of genomics, proteomics and metabolomics, some indicators related to the occurrence or development of nervous system diseases, such as BDNF, GFAP, SAA, etc., have been found to be early diagnosis of some neurological diseases. An indicator of prognostic diagnosis.
