Editing Luciferas 4T1 Breast Cancer Cells(4T1-Luc)

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Summary	<p><span data-slate-node="text">The 4T1-LUC cell line is a widely used murine breast cancer cell line that has been engineered to express the luciferase gene, allowing for non-invasive monitoring of tumor growth and metastasis in live animals using bioluminescence imaging. </span><span data-slate-node="text">The 4T1 cell line was originally derived from a spontaneously arising mammary tumor in a BALB/cfC3H mouse and has since become a valuable model for studying breast cancer progression and metastasis.</span></p><p><span data-slate-node="text">By introducing the luciferase reporter gene into the 4T1 cell line, researchers can easily track the growth of primary tumors and the spread of metastatic lesions in preclinical studies. </span><span data-slate-node="text">Luciferase-expressing cells emit light when they come into contact with a specific substrate, such as luciferin, allowing for real-time visualization and quantification of tumor growth and dissemination in vivo.</span></p><p><span data-slate-node="text">The 4T1-LUC cell line is known for its high metastatic potential, resembling aggressive forms of breast cancer in patients. </span><span data-slate-node="text">This cell line is commonly used to investigate key aspects of breast cancer biology, including tumor invasion, metastasis to distant organs, immune interactions, and responses to various therapeutic interventions.</span></p><p><br/></p>
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