Editing U-2OS Osteosarcoma Cells(U-2OS)

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Summary	<p>U-2 OS is a cell line with epithelial morphology that was derived in 1964 from a moderately differentiated sarcoma of the tibia of a 15-year-old, White, female osteosarcoma patient.</p><p><span >Osteosarcoma is the most common primary malignant bone tumor, and U-2OS is a common osteosarcoma cell model.&nbsp; The constructed U-2OS tool cell line could effectively edit protein-coding gene (ETV4) and long non-coding RNA gene (MALAT1). The results of this study also indicated that the constructed U-2OS tool cell line could greatly improve the efficiency of gene editing. Therefore, the genetic engineering cell line provided by the study is of great significance for studying the pathogenesis and regulatory network of osteosarcoma, and for preventing and treating bone tumor as soon as possible.</span></p>
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