Editing Tumor Necrosis Factor Ligand Superfamily, Member 7(TNFSF7)

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Summary	CD70 is a surface antigen found on activated, but not resting, The predicted 193-amino acid protein, has a 20-amino acid hydrophilic N-terminal domain that lacks a signal sequence; an 18-amino acid hydrophobic region that presumably functions as a transmembrane anchor; and a C-terminal domain that contains 2 potential N-linked glycosylation sites. Based on these features, the authors suggested that the C-terminal domain of CD27L is extracellular, and thus classified CD27L as a type II transmembrane protein. CD27L is homologous to the ligands of the TNF receptor family, including TNF-alpha, TNF-beta, and the CD40 ligand, showing 19 to 24% amino acid sequence identity in the extracellular region.
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