Editing Hypoxia Inducible Factor 1 Alpha(HIF1a)

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Summary	<p>The HIF (hypoxia-inducible factor) transcription factor is a member of the basic-helix-loop-helix (bHLH) family of transcription factors and plays an important role in maintaining cellular oxygen homeostasis. The hypoxia-inducible transcription factor 1&alpha; (HIF-1&alpha;) is the regulated member of the transcription factor heterodimer HIF-1. HIF-1&alpha; has emerged as an important drug target in breast and prostate cancer, cardiovascular disease, and ischemia.</p><p>HIF-1alpha abundance (and its subsequent activity) is regulated transcriptionally in an NF-&kappa;B dependent manner. In addition, the coordinated activity of the prolyl hydroxylases (PHDs) maintain the appropriate balance of HIF-1&alpha; protein in the post-translation phase.</p>
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