Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)


The antibody is a mouse monoclonal antibody raised against Ab1-42. It has been selected for its ability to recognize Ab1-42 in immunohistochemical staining and western blotting.


Western blotting: 0.5-2µg/mL;1:220-900
Immunohistochemistry: 5-20µg/mL;1:22-90
Immunocytochemistry: 5-20µg/mL;1:22-90
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Magazine Citations
Neuropsychopharmacology Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease Pubmed: 23493042
Neuropharmacology and analgesia The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1–42 seeding and short-term memory deficits in the Aβ25–35 mouse model of Alzheimer's disease Pubmed: 23123349
世界科技研究与发展(World Sci-tech R & D) 慢病毒介导的CBS基因过表达对原代皮质神经元 Globesci:Source
南方医科大学学报 外源性硫化氢对高糖条件下原代神经元β淀粉样蛋白的影响 J-Smu:Source
Neurochemical research Effects of Aluminium on β-Amyloid (1–42) and Secretases (APP-Cleaving Enzymes) in Rat Brain Pubmed:24792732
Indian J Biochem Biophys. Amyloid ? lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity Pubmed:25296496
Cell Mol Neurobiol Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells PubMed: 25809614
Neuropsychiatr Dis Treat Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex PubMed: 26316755
Neurochem Int Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS2 transgenic model of Alzheimer's disease PubMed: 25882166
Journal of Alzheimer’s Parkinsonism & Dementia The Potential Effect of Epigallocatechin-3-Gallate alone or in Combination with Vitamin E and Selenium on Alzheimer's Disease Induced by Aluminum in Rats open-access:
世界科技研究与发展 芝麻素对高糖条件下PC12细胞Aβ和BACE-1表达的影响 article:10299
Am J Alzheimers Dis Other Demen. Tong Luo Jiu Nao, a Chinese Medicine Formula, Reduces Inflammatory Stress in a Mouse Model of Alzheimer's Disease Pubmed:26993489
世界科技研究与发展 芝麻素对高糖条件下PC12 细胞Aß 和BACE 1 表达的影响 QK:92621A
Archives of Pharmacal Research Geniposide attenuates the level of Aβ1–42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice pubmed:28160136
Food Funct. Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease. pubmed:28232989
Scientific Reports Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease articles:srep41041.ris
Journal of Medicinal Food Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells pubmed:28406733
Journal of Nutritional Biochemistry Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet Pubmed:29986309
Biochemical Pharmacology Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats Pubmed:30028991
Journal of Affective Disorders Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats Pubmed:29879605
Biomedicine & Pharmacotherapy Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain modulating apoptotic mediator … Pubmed:29579708
Journal of Agricultural and Food Chemistry Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice Pubmed:29695154
Neurotoxicology Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats Pubmed:29522778
Biochemical and Biophysical Research Communications CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease Pubmed:29777699
Oncotarget Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-β deposition in the J20 mouse … Pubmed:29731975
Experimental and Therapeutic Medicine Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation Doi: 10.3892/etm.2018.6860
非编码RNA miR-137 调控tau 蛋白磷酸化和L 型钙离子通道CACNA1C 参与阿尔茨海默病的发生
台湾农业研究 (台灣農業研究67 (4): 355-364) 香菇柄水萃物改善糖尿病降低阿茲海默氏症罹病風險初探
The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer's
Neurotoxicity Research Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells Pubmed: 30649678
Neurochemical Research Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation Pubmed: 30756214
Molecular and Cellular Biochemistry Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β level
PLoS One Obstructive sleep apnea may increase the risk of Alzheimer's disease Pubmed: 31487291
Metabolic Brain Disease Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and … Pubmed: 31728888
博士论文 Neurobiological determinants of depressive-like symptoms in rodents
Pharmacognosy Magazine Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced …
biosciences biotechnology research asia Dietary Malted Barley Grain Improved Structure and Function of Spinal Cord of Mother Rats fed on a high cholesterol diet.
Catalog No. Related products for research use of Organism species Applications (RESEARCH USE ONLY!)
MAA946Mi21 Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42) WB; IHC; ICC; IP.
CEA946Mi ELISA Kit for Amyloid Beta Peptide 1-42 (Ab1-42) Enzyme-linked immunosorbent assay for Antigen Detection.