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Mouse Model for Peritoneal Fibrosis (PF)

PF; Peritoneal Fibrosis

  • Product No.DSI819Mu01
  • Organism SpeciesMus musculus (Mouse) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceIntraperitoneal injection（I.P） of high glucose dialysate
  • Model Animal StrainsKM mice (SPF), healthy, male, 6~8 weeks
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4w
  • Modeling Method1.Mice were intraperitoneally injected with 4.25% high glucose dialysate (100ml/kg) and LPS (0.1mg/kg) once a day for four weeks.

    2.Measure the peritoneal function and take tissue from the parietal peritoneum and visceral peritoneum (mesentery) for relevant indicators.
  • ApplicationsUsed to study the process and pharmacodynamics of peritoneal fibrosis
  • Downloadn/a
  • UOM Each case
  • FOB US$ 240 
    For more details, please contact local distributors!

Model Evaluation

1. Observe the changes in peritoneal thickness of experimental animals in each group using Masson staining. Compared with the normal control group, Masson staining showes that the model group had significantly thickened peritoneum, increased extracellular matrix, increased collagen fibers, and significant changes in peritoneal fibrosis.

Pathological Results

2. Western blot and Q-PCR detection of fibronectin (FN) and smooth muscle protein（ α- SMA), E. cadherin, expression of type I collagen (Col I).

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Mus musculus (Mouse) Organism species Applications (RESEARCH USE ONLY!)
DSI819Mu01 Mouse Model for Peritoneal Fibrosis (PF) Used to study the process and pharmacodynamics of peritoneal fibrosis