Rat Model for Necrotizing Enterocolitis (NEC)

  • Product No.DSI730Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by artificial feeding and induction of hypoxia and cold stimulation
  • Model Animal StrainsNeonatal SD rats(SPF), 2 days old
  • Modeling Grouping1.Randomly divided into six group: Control group, Model group, Positive drug group and Te
  • Modeling Period1~2 weeks
  • Modeling Method1. The birth of 2 day's neonatal SD rats and separated from maternal rats, using the self-made 24 G closed venous indwelling needle to connect with the 1 ml injector instead of the gastric tube to feed the milk,feed the tats 4 times a day by oral intubation, each intubation depth of about 2 cm.The first feeding amount was 0.1 ml/ times, every 24 hours increased by 0.1ml/ times, after 48 hours gradually increased to the amount of 0.3 ml/ times.
    2. After feeding 2 times a day, the newborn SD rats were placed in the self-made hypoxia cabin, zero oxygen measuring instrument, input the neonatal rat to the nitrogen (15 L/min flow) for 90 s, and then a self-made 4 degrees cold box for 10 min continuous cold stimulation.
    3. NEC model of neonatal SD rats was established for 3 days continuously. The rats were sacrificed at 12 h after the last feeding.
  • ApplicationsDisease Model
  • Downloadn/a
  • UOM Each case
  • FOB US$ 150 
    For more details, please contact local distributors!

Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.



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DSI730Ra01 Rat Model for Necrotizing Enterocolitis (NEC) Disease Model