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Mouse Model for Chronic Stress Depression (CSD)

  • Product No.DSI704Mu01
  • Organism SpeciesMus musculus (Mouse) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by medicine
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
  • Modeling Method(1)"Male mice weight 20 ~ 22g. In dose of 2mg/kg body weight for intravenous injection of reserpine, while injection of the tested drug or saline,after 1h, observe in 15S within the animal ptosis of the situation. Before the experiment, the rectal temperature was measured three times, and the mean value was taken as the basal body temperature, then injection of reserpine in dose of 2 mg/kg body weight, the tested drug or saline was administered at the same time. At 6 hours after administration, the difference between the rectal temperature at each time point was compared between the administration group and the saline control group.When the animal body temperature was measured, the ambient temperature should be kept constant, preferably about 20 degrees. In dose of 2.5mg/Kg body weight of intravenous injection of reserpine, while the drug to be tested or saline, after 1h the animals are placed in the diameter of 7.5 cm round white paper for 15 s observation, compared with the control group and control group still The number of animals in the circle."(2)Male and female mice, weight 20 ~ 24 g. Before the experiment with an electronic thermometer measured by the anus temperature 3 times, and its valeurs are as the basal body temperature.Then given the tested drug or saline, 30 min after 16 mg / Kg of body weight at the dose of apomorphine injection, to apomorphine 30 min after the temperature again measured, compared with the control group and saline control group of rectal temperature difference in the ambient temperature should be maintained at about 20 degrees.
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  • UOM Each case
  • FOB US$  
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Model Evaluation

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Mus musculus (Mouse) Organism species Applications (RESEARCH USE ONLY!)
DSI704Mu01 Mouse Model for Chronic Stress Depression (CSD) n/a