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Interleukin 28B (IL28B)

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IFNL3; Interferon,Lambda 3; Cytokine Zcyto22

Interleukin 28B (IL28B)
CCC C028
HGNC 18365
PubMed 20803561
UniProt Q8IZI9
Wiki IL28B

IL28B is a class II cytokine receptor ligand related to type I interferons . These ligands play a critical role in response to microbial challenge and activate the JAK /STAT signaling system (Sheppard et al., 2003). By genomic sequence analysis, Sheppard et al. (2003) identified genes encoding IL28A , IL28B, and IL29. The deduced 200-amino acid IL28B protein is 96% identical to IL28A and 81% identical to IL29, but it shares only low homology with IL10 , IFNA2, and IL22 .

IL28B has a conserved cysteine pattern and amphipathic profile similar to other helical cytokine family members. By genomic sequence analysis, Sheppard et al. (2003) determined that the IL28B gene contains 6 exons, in contrast to the related type I IFNs, which are encoded by a single exon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APC028Hu01 Active Interleukin 28B (IL28B) Cell culture; Activity Assays.
RPC028Hu01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAC028Hu22 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
LAC028Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC.
LAC028Hu81 FITC-Linked Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
PAC028Hu01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
Assay Kits SEC028Hu ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC028Hu CLIA Kit for Interleukin 28B (IL28B) Chemiluminescent immunoassay for Antigen Detection.
HEC028Hu High Sensitive ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 28B (IL28B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 28B (IL28B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 28B (IL28B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 28B (IL28B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 28B (IL28B) ELISA Kit Customized Service Offer
  1. "IL-28, IL-29 and their class II cytokine receptor IL-28R." Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  2. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
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  8. "Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family."J. Biol. Chem. 284:20869-20875(2009) [PubMed] [Europe PMC] [Abstract]