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S100 Calcium Binding Protein A9 (S100A9)

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MRP14; MIF; 60B8AG; CFAG; NIF; CAGB; CGLB; L1AG; P14; Calgranulin B; Migration inhibitory factor-related protein 14; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain

S100 Calcium Binding Protein A9 (S100A9)
CCC B793
HGNC 10499
MGI 1338947
PubMed 22470535
RGD 620267
UniProt P06702
Wiki S100A9

S100 calcium binding protein A9 has been implicated in the abnormal differentiation of myeloid cells in the stroma of cancer. This contributes to creating an overall immunosuppressive microenvironemnt that may contribute to the inability of a protective or therapeutic cellular immune response to be generated by the tumor-bearing host.

Outside of malignancy, S100A9 in association with its dimerization partner, S100A8 (MRP8 or calgranulin A) signals for lymphocyte recruitment in sites of inflammation. S100A9/A8 (synonyma: Calgranulin A/B; Calprotectin) are also regarded as marker proteins for a number of inflammatory diseases in humans, especially in rheumatoid arthritis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB793Hu01 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
APB793Hu01 Active S100 Calcium Binding Protein A9 (S100A9) Cell culture; Activity Assays.
Antibodies PAB793Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
MAB793Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC
LAB793Hu82 FITC-Linked Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IF.
LAB793Hu72 Biotin-Linked Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC.
LAB793Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC.
LAB793Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IF.
MAB793Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC
MAB793Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB
MAB793Hu27 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
MAB793Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC
MAB793Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
MAB793Hu29 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
Assay Kits SEB793Hu ELISA Kit for S100 Calcium Binding Protein A9 (S100A9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB793Mu01 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
RPB793Mu02 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB793Mu01 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
LAB793Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC.
LAB793Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IF.
PAB793Mu02 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
Assay Kits SEB793Mu ELISA Kit for S100 Calcium Binding Protein A9 (S100A9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB793Ra01 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB793Ra01 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
LAB793Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC.
Assay Kits SEB793Ra ELISA Kit for S100 Calcium Binding Protein A9 (S100A9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB793Ca01 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB793Ca01 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A9 (S100A9) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A9 (S100A9) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB793Bo01 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
RPB793Bo02 Recombinant S100 Calcium Binding Protein A9 (S100A9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB793Bo01 Polyclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
MAB793Bo21 Monoclonal Antibody to S100 Calcium Binding Protein A9 (S100A9) WB; IHC; ICC; IP.
Assay Kits SEB793Bo ELISA Kit for S100 Calcium Binding Protein A9 (S100A9) Enzyme-linked immunosorbent assay for Antigen Detection.
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  21. "Anti-infective protective properties of S100 calgranulins."Antiinflamm. Antiallergy Agents Med. Chem. 8:290-305(2009) [PubMed] [Europe PMC] [Abstract]
  22. "A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway."Biochem. J. 422:363-372(2009) [PubMed] [Europe PMC] [Abstract]
  23. "S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis."Eur. J. Pharmacol. 625:73-83(2009) [PubMed] [Europe PMC] [Abstract]
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  25. "Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion."J. Biol. Chem. 284:7078-7090(2009) [PubMed] [Europe PMC] [Abstract]
  26. "The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer."J. Leukoc. Biol. 86:557-566(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides."PLoS Biol. 7:E97-E97(2009) [PubMed] [Europe PMC] [Abstract]
  28. "S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3."Cell Res. 20:314-331(2010) [PubMed] [Europe PMC] [Abstract]
  29. "S100 Calgranulins in inflammatory arthritis."Immunol. Cell Biol. 88:41-49(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism."J. Leukoc. Biol. 87:905-914(2010) [PubMed] [Europe PMC] [Abstract]
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  34. "Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis."J. Immunol. 186:3622-3631(2011) [PubMed] [Europe PMC] [Abstract]
  35. "S100A8 and S100A9 in cardiovascular biology and disease."Arterioscler. Thromb. Vasc. Biol. 32:223-229(2012) [PubMed] [Europe PMC] [Abstract]
  36. "Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent."Immunology 137:172-182(2012) [PubMed] [Europe PMC] [Abstract]
  37. "Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction."Inflammation 35:409-419(2012) [PubMed] [Europe PMC] [Abstract]
  38. "Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes."Int. J. Mol. Sci. 13:2893-2917(2012) [PubMed] [Europe PMC] [Abstract]
  39. "S100A8 and S100A9: new insights into their roles in malignancy."J. Innate Immun. 4:31-40(2012) [PubMed] [Europe PMC] [Abstract]
  40. "Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation."PLoS ONE 7:E40277-E40277(2012) [PubMed] [Europe PMC] [Abstract]
  41. "MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization."PLoS ONE 7:E32953-E32953(2012) [PubMed] [Europe PMC] [Abstract]
  42. "Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway."PLoS ONE 7:E29333-E29333(2012) [PubMed] [Europe PMC] [Abstract]
  43. "Target-selective protein S-nitrosylation by sequence motif recognition."Cell 159:623-634(2014) [PubMed] [Europe PMC] [Abstract]
  44. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  45. "The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process."J. Mol. Biol. 316:265-276(2002) [PubMed] [Europe PMC] [Abstract]
  46. "The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins."J. Mol. Biol. 370:887-898(2007) [PubMed] [Europe PMC] [Abstract]