Integrin Alpha V (ITGaV)

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CD51; ITG-AV; MSK8; VNRA; Vitronectin Receptor,Alpha Polypeptide

Integrin Alpha V (ITGaV)
Integrin Alpha V encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB282Hu01 Recombinant Integrin Alpha V (ITGaV) Positive Control; Immunogen; SDS-PAGE; WB.
RPB282Hu02 Recombinant Integrin Alpha V (ITGaV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB282Hu01 Polyclonal Antibody to Integrin Alpha V (ITGaV) WB
MAB282Hu22 Monoclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
PAB282Hu02 Polyclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
MAB282Hu21 Monoclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
MAB282Hu23 Monoclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
MAB282Hu24 Monoclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
MAB282Hu25 Monoclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
Assay Kits SEB282Hu ELISA Kit for Integrin Alpha V (ITGaV) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB282Mu01 Recombinant Integrin Alpha V (ITGaV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB282Mu01 Polyclonal Antibody to Integrin Alpha V (ITGaV) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha V (ITGaV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha V (ITGaV) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB282Ra01 Recombinant Integrin Alpha V (ITGaV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Integrin Alpha V (ITGaV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Alpha V (ITGaV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Alpha V (ITGaV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha V (ITGaV) ELISA Kit Customized Service Offer
  1. "Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs."J. Biol. Chem. 262:14080-14085(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51."Cytogenet. Cell Genet. 89:268-271(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The integrin alpha v gene: identification and characterization of the promoter region."Biochim. Biophys. Acta 1219:228-232(1994) [PubMed] [Europe PMC] [Abstract]
  7. "cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors."Proc. Natl. Acad. Sci. U.S.A. 83:8614-8618(1986) [PubMed] [Europe PMC] [Abstract]
  8. "A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells."Cell 57:59-69(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells."Virology 239:71-77(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
  11. "The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus."J. Virol. 74:4949-4956(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains."Biochemistry 42:12950-12959(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9."J. Virol. 78:6967-6973(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments."Dev. Cell 13:496-510(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor."J. Virol. 82:1570-1580(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity."Biochemistry 52:7082-7090(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of the extracellular segment of integrin alpha Vbeta3."Science 294:339-345(2001) [PubMed] [Europe PMC] [Abstract]