S100 Calcium Binding Protein B (S100B)

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S100-B; NEF; S100Beta; S-100 protein subunit beta

S100 Calcium Binding Protein B (S100B)

S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA567Hu01 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
APA567Hu01 Active S100 Calcium Binding Protein B (S100B) Cell culture; Activity Assays.
Antibodies PAA567Hu01 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC
MAA567Hu22 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Hu92 HRP-Linked Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Hu82 FITC-Linked Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IF.
LAA567Hu72 Biotin-Linked Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IF.
MAA567Hu21 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Hu23 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Hu24 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Hu25 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Hu27 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Hu29 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
Assay Kits SEA567Hu ELISA Kit for S100 Calcium Binding Protein B (S100B) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA567Hu CLIA Kit for S100 Calcium Binding Protein B (S100B) Chemiluminescent immunoassay for Antigen Detection.
IEA567Hu Instant ELISA Kit for S100 Calcium Binding Protein B (S100B) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA567Hu ELISA Kit for Anti-S100 Calcium Binding Protein B Antibody (Anti-S100B) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA567Mu01 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
RPA567Mu02 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
APA567Mu01 Active S100 Calcium Binding Protein B (S100B) Cell culture; Activity Assays.
Antibodies PAA567Mu01 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IF.
PAA567Mu02 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
MAA567Mu21 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Mu72 Biotin-Linked Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
Assay Kits SEA567Mu ELISA Kit for S100 Calcium Binding Protein B (S100B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA567Ra01 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
APA567Ra01 Active S100 Calcium Binding Protein B (S100B) Cell culture; Activity Assays.
Antibodies PAA567Ra01 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Ra81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IF.
MAA567Ra21 Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Ra72 Biotin-Linked Monoclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
Assay Kits SEA567Ra ELISA Kit for S100 Calcium Binding Protein B (S100B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA567Rb01 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA567Rb52 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
PAA567Rb51 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
LAA567Rb71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC.
LAA567Rb81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IF.
PAA567Rb01 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
Assay Kits SEA567Rb ELISA Kit for S100 Calcium Binding Protein B (S100B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA567Bo01 Recombinant S100 Calcium Binding Protein B (S100B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA567Bo01 Polyclonal Antibody to S100 Calcium Binding Protein B (S100B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein B (S100B) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein B (S100B) ELISA Kit Customized Service Offer
  1. "Cloning and expression of the human S100 beta gene."J. Biol. Chem. 265:15537-15543(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta."J. Neurochem. 45:700-705(1985) [PubMed] [Europe PMC] [Abstract]
  5. "Purification, characterization and ion binding properties of human brain S100b protein."Biochim. Biophys. Acta 790:164-173(1984) [PubMed] [Europe PMC] [Abstract]
  6. "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma."Exp. Cell Res. 246:501-509(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding."J. Biol. Chem. 285:40762-40770(2010) [PubMed] [Europe PMC] [Abstract]
  8. "The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A."Mol. Cell. Biol. 30:2724-2736(2010) [PubMed] [Europe PMC] [Abstract]
  9. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  10. "A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form."Structure 6:211-222(1998) [PubMed] [Europe PMC] [Abstract]
  11. "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex."J. Biol. Chem. 278:6251-6257(2003) [PubMed] [Europe PMC] [Abstract]